Results 91 to 100 of about 3,788,206 (312)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Legitimizing radical new medical services [PDF]

open access: yes, 2011
Physicians enjoy considerable liberty in the creation of entrepreneurial ventures in the new frontiers of medicine. Professional societies may opine about a new procedure but professionals may feel free to ignore their counsel as well.
Clinch, Nanette C, Osland, A, Wang, C
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Managing for change: September 20, 1991 v. 2, no. 6 [PDF]

open access: yes, 1991
Bi-weekly newsletter of University Hospital's Change Project, provided to managers at the ...
Abercrombie, J. Scott, Jr.   +1 more
core  

MEDICAL SERVICES; QUALITY & ITS ATTRIBUTES

open access: yesTHE PROFESSIONAL MEDICAL JOURNAL, 2016
A better health care delivery system is dependent on many factors. For effectivehealth delivery, its important to identify those factors. Objectives: This study was conducted tostudy the factors responsible for health care delivery system in a tertiary care hospital. Studydesign: An exploratory study. Period: June 2015 to August 2015.
Zohra Khanum, Amna Khanum, Fatima Khanum
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Managing for change: March 5, 1992 v. 3, no. 2 [PDF]

open access: yes, 1992
Bi-weekly newsletter of University Hospital's Change Project, provided to managers at the ...
Abercrombie, J. Scott, Jr.   +1 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Managing for change: October 25, 1991 v. 2, no. 7 [PDF]

open access: yes, 1991
Bi-weekly newsletter of University Hospital's Change Project, provided to managers at the ...
Abercrombie, J. Scott, Jr.   +1 more
core  

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