Results 91 to 100 of about 1,132,900 (337)

2D Detectors for Particle Physics and for Imaging Applications

, 2005
The demands on detectors for particle detection as well as for medical and astronomical X-ray imaging are continuously pushing the development of novel pixel detectors.
Amati, Amendolia, Andricek, Blanquart, Brönnimann, Busse, Campbell, Choquette, Claus, Delpierre, Delpierre, Deptuch, Dulinski, Eikenberry, Erdmann, Fischer, Fischer, Fischer, Flick, Gatti, Gay, Gemme, Graafsma, Granfors, Gys, H. Krüger, Jarron, Jung, Kemmer, Kenney, Kenney, Kucewicz, Kucewicz, Kwan, Lindner, Lindström, Llopart, Löcker, Marczewski, Matis, Mettivier, Meynants, Niederlöhner, Riedler, Snoeys, Theil, Tousignant, Trimpl, Turchetta, Turchetta, Wermes   +50 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A new texture-based labeling framework for hyper-reflective foci identification in retinal optical coherence tomography images

Scientific Reports
An important abnormality in Optical Coherence Tomography (OCT) images is Hyper-Reflective Foci (HRF). This anomaly can be interpreted as a biomarker of serious retinal diseases such as Age-related Macular Degeneration (AMD) and Diabetic Macular Edema ...
Maryam Monemian, Parisa Ghaderi Daneshmand, Sajed Rakhshani, Hossein Rabbani   +3 more
doaj   +1 more source

An investigation of linear correlation for a new alternative hardware approach to process the medical wearable sensor signals [PDF]

, 2021
Muhideen Abbas Hasan, Sadik Kamel Gharghan, Manaf Adnan Farhood   +2 more
openalex   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Novel computation of pulse transit time from multi-channel PPG signals by wavelet transform

Current Directions in Biomedical Engineering, 2016
Being able to accurately monitor blood pressure in a reliable, truly non-invasive manner is a highly sought after goal within the biomedical community.
Pielmuş Alexandru-Gabriel, Pflugradt Maik, Tigges Timo, Klum Michael, Feldheiser Aarne, Hunsicker Oliver, Orglmeister Reinhold   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source