Results 121 to 130 of about 554,094 (312)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Behaviour and burnout in medical students [PDF]

, 2014
Background: Burnout is prevalent in doctors and can impact on job dissatisfaction and patient care. In medical students, burnout is associated with poorer self-rated health; however, it is unclear what factors influence its development.
Anita Laidlaw, Hart, Jo, Laidlaw, A, McHale, Calum T, Calum McHale, Cecil, Joanne Elizabeth, Jo Hart, Jo Cecil, McHale, C, Laidlaw, Anita Helen, Cecil, Joanne, McHale, Calum Thomas, Hart, J; id_orcid, Cecil, J   +13 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comparison of 2D and 3D multichannel audio rendering methods for hearing research applications using technical and perceptual measures

Acta Acustica
Virtual reality with multichannel audio playback is increasingly used in hearing aid research. The purpose of this study is to compare horizontal (2D) and periphonic (3D) rendering methods in terms of localization, minimum audible angle, and perceptual ...
Gerken Merle, Hohmann Volker, Grimm Giso
doaj   +1 more source

Signal Processing and Communications Applications Conference [PDF]

, 2015
In order to assess the health status of newborn babies, a practical method called Apgar score is used. By looking at Apgar score, medics decide whether the newborn need any attention such as resuscitation or intubation. Determining the possibility of the
Bozkurt, Ferda, Baris Doruk Gungor, Uçar, Muhammed Kürşad   +2 more
core  

A robust physiology-based source separation method for QRS detection in low amplitude fetal ECG recordings. [PDF]

, 2010
The use of the non-invasively obtained fetal electrocardiogram (ECG) in fetal monitoring is complicated by the low signal-to-noise ratio (SNR) of ECG signals. Even after removal of the predominant interference (i.e.
P F F Wijn, Vullings, R., J W M Bergmans, C H L Peters, M J M Hermans, Peters, CHL Chris, Oei, SG Guid, Oei, S.G., Peters, C.H.L., Hermans, MJM, Bergmans, JWM Jan, Bergmans, J.W.M., Vullings, R Rik, S G Oei, Hermans, M.J.M., Wijn, P.F.F., R Vullings, Vullings, R.; id_orcid, Wijn, PFF Pieter   +18 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Image processing in echography and MRI [PDF]

, 2005
This work deals with image processing for three medical imaging applications: speckledetection in 3D ultrasound, left ventricle detection in cardiac magnetic resonance imaging(MRI) and flow feature visualisation in velocity MRI.For speckle detection, a ...
Carmo, Bernardo S., Carmo, Bernardo S
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source