Results 61 to 70 of about 554,094 (312)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

In-ear photoplethysmography for central pulse waveform analysis in non-invasive hemodynamic monitoring

Current Directions in Biomedical Engineering, 2017
In recent years, the analysis of the photoplethys-mographic (PPG) pulse waveforms has attracted much research focus. However, the considered signals are primarily recorded at the fingertips, which suffer from reduced peripheral perfusion in situations ...
Tigges Timo, Rockstroh Jonas, Pielmuş Alexandru, Klum Michael, Feldheiser Aarne, Hunsicker Oliver, Orglmeister Reinhold   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Simulation study of a low-cost Slide-Through PET scanner based on narrow flat panels with monolithic detectors

Frontiers in Physics
BackgroundPatient throughput in conventional PET systems is constrained by limited system sensitivity and the need for bed positioning. This study proposes a cost-effective Slide-Through PET (ST-PET) design based on two narrow monolithic LYSO detector ...
Elke Dhaenens, Boris Vervenne, Maya Abi Akl, Jens Maebe, Christian Vanhove, Stefaan Vandenberghe   +5 more
doaj   +1 more source

Optimal Deep Learning Architecture for Automated Segmentation of Cysts in OCT Images Using X-Let Transforms

Diagnostics, 2023
The retina is a thin, light-sensitive membrane with a multilayered structure found in the back of the eyeball. There are many types of retinal disorders.
Reza Darooei, Milad Nazari, Rahele Kafieh, Hossein Rabbani   +3 more
doaj   +1 more source

Challenges Associated with the Safety Signal Detection Process for Medical Devices

Medical Devices: Evidence and Research, 2021
Previous safety issues involving medical devices have stressed the need for better safety signal detection. Various European Union (EU) national competent authorities have started to focus on strengthening the analysis of vigilance data. Consequently, article 90 of the new EU regulation states that the European Commission shall put in place systems and
Josep Pane, Katia MC Verhamme, Dorian Villegas, Laura Gamez, Irene Rebollo, Miriam CJM Sturkenboom   +5 more
openaire   +6 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Quantitative analysis of patient motion in walk-through PET scanner and standard axial field of view pet scanner using infrared-based tracking

EJNMMI Physics
Background Long-axial field-of-view (LAFOV) Positron Emission Tomography (PET) scanners provide high sensitivity, but throughput is limited because of time-consuming patient positioning.
Rabia Aziz, Jens Maebe, Florence Marie Muller, Yves D’Asseler, Stefaan Vandenberghe   +4 more
doaj   +1 more source

Classification of morphologic changes in photoplethysmographic waveforms

Current Directions in Biomedical Engineering, 2016
An ever increasing number of research is examining the question to what extent physiological information beyond the blood oxygen saturation could be drawn from the photoplethysmogram.
Tigges Timo, Music Zenit, Pielmus Alexandru, Klum Michael, Feldheiser Aarne, Hunsicker Oliver, Orglmeister Reinhold   +6 more
doaj   +1 more source

Pannexin 1 Is Critically Involved in Feedback from Horizontal Cells to Cones

Frontiers in Molecular Neuroscience, 2017
Retinal horizontal cells (HCs) feed back negatively to cone photoreceptors and in that way generate the center/surround organization of bipolar cell receptive fields. The mechanism by which HCs inhibit photoreceptors is a matter of debate.
Valentina Cenedese, Wim de Graaff, Tamás Csikós, Mitali Poovayya, Georg Zoidl, Maarten Kamermans, Maarten Kamermans   +6 more
doaj   +1 more source