Results 51 to 60 of about 785,951 (306)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Support and Assessment for Fall Emergency Referrals (SAFER 1) trial protocol. Computerised on-scene decision support for emergency ambulance staff to assess and plan care for older people who have fallen: evaluation of costs and benefits using a pragmatic cluster randomised trial [PDF]

, 2010
Background: Many emergency ambulance calls are for older people who have fallen. As half of them are left at home, a community-based response may often be more appropriate than hospital attendance.
Russell Ian, Lyons, Ronan, Peconi, Julie, Lyons, R., Wells, B., Humphreys, I., Whitfield, R, Humphreys, Ioan, Sánchez, A, Dale, J, Russell, I, Lyons, R, Mason Suzanne, Helen Snooks, Gaze, Sarah, Sánchez, Antonio, Dale, J., Snooks Helen, Wani, M, Roberts Stephen, Suzanne Mason, Dale, Jeremy, Dale Jeremy, Yasmin Merali, Ceri Phillips, Merali, Yasmin, Wells, B, Close Jacqueline, Sarah Gaze, Snooks, Helen, Russell, Ian, Whitfield, Richard, Lyons Ronan, Ivy Cheung, Stephen Roberts, Mason, Suzanne, Snooks, H., Roberts, Stephen, Julie Peconi, Whitfield, R., Jacqueline Close, Peconi, J., Cheung Wai-Yee, Humphreys, I, Merali Yasmin, Peconi Julie, Phillips, Ceri, Sánchez, A., Humphreys Ioan, Wells Bridget, Mason, S, Russell, Ian T., Phillips Ceri, Roberts, S., Wani, M., Close, Jacqueline, Phillips, J., Cheung, Wai-Yee, Merali, Y., Cheung, WY, Ian Russell, Phillips Judith, Wani Mushtaq, Gaze, S., Roberts, Stephen E., Merali, Y, Gaze, S, Close, J ; https://orcid.org/, Phillips, Judith, Phillips, C., Russell, I., Judith Phillips, Ronan Lyons, Whitfield Richard, Cheung, W.-Y., Close, J., Wells, Bridget, Mason, S., Peconi, J, Phillips, J, Sánchez Antonio, Antonio Sánchez, Richard Whitfield, Roberts, S, Ioan Humphreys, Jeremy Dale, Snooks, H, Bridget Wells, Wai-Yee Cheung, Gaze Sarah, Mushtaq Wani, Wani, Mushtaq, Phillips, C   +92 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Os médicos e a racionalização das práticas hospitalares: novos limites para a liberdade profissional?

Saúde em Debate
Os hospitais brasileiros experimentam um marcado processo de racionalização de suas práticas na busca de maiores eficiência e eficácia organizacional.
Carolina Chaccur Abou Jamra, Luiz Carlos de Oliveira Cecilio, Tiago Correia   +2 more
doaj   +1 more source

Efficient utilization of the limited number of emergency medicine specialists and statistics related to clinical outcomes in the emergency department [PDF]

Clinical and Experimental Emergency Medicine, 2016
Objective The supply of emergency medicine (EM) specialists has not been able to meet demand in the past decade. This study comparatively analyzed clinical findings to provide fundamental data to inform efficient utilization of a limited number of EM ...
Jae Hyun Kwon, Chang Hwan Sohn, Jae Ho Lee, Bum Jin Oh   +3 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Factors affecting the resilience of hospital medical staff during the COVID-19 pandemic

Family Medicine & Primary Care Review, 2023
HAMID JAFARI, Mohammad Heidari, Reza Sadeghi, MAJID HEIDARI-JAMEBOZORGI   +3 more
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source