Results 71 to 80 of about 767,632 (258)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Psychological Status of Medical Staff in Obstetrics and Gynecology Hospitals during the Omicron Pandemic Outbreak in China

Canadian Journal of Infectious Diseases and Medical Microbiology
Background. Medical staff in China faced great challenges and psychological and physiological changes of varying degrees during the omicron epidemic outbreak.
Shuting Bao, Bangwu Chen, Ying Hu, Chee Shin Lee, Qi Wu, Menglin Zhou, Mengkai Du, Shuqi Zhu, Biao Xie, Jiuqiong Hu, Zhaoxia Liang   +10 more
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

What is the most important factor affecting patient satisfaction – a study based on gamma coefficient

Patient Preference and Adherence, 2019
Jinming Fang,1,2 Ling Liu,2 Pengqian Fang11School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China; 2Wuhan Forth Hospital, Puai Hospital, Tongji ...
Fang J, Liu L, Fang P
doaj  

Sexual Satisfaction of Hospital Medical Staff During the COVID-19 Pandemic

Armaghane Danesh Bimonthly Journal, 2022
Hospital medical staff were less sexually active during the COVID-19 pandemic due to networking, distance from family, and COVID-19 anxiety. Given that nearly two years have passed since the outbreak of COVID-19 in the world and we are still witnessing ...
F Bagheri Sheykhangafshe
doaj  

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Attitude toward the Patient Safety Culture in healthcare systems [PDF]

Patient Safety and Quality Improvement Journal, 2016
Introduction: Patient Safety Culture (PSC) involves a harmonious pattern of individual and organization behaviors based on common beliefs and values.
Fereydoon Laal, Babak Fazli, Davoud Balarak, Forouzan Dalir, Mahdi Mohammadi, Ramazan Mirzaei   +5 more
doaj  

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Biomedical Waste Management: Awareness and Practices in A District Of Madhya Pradesh

National Journal of Community Medicine, 2011
Background: A hospital is an establishment that provides medical care facilities. Since the majority of the persons receiving treatment in the hospital are suffering with infectious diseases therefore, the waste generated in hospital has potential to ...
Manoj Bansal, Ashok Mishra, Praveen Gautam, Richa Changulani, Dhiraj Srivastava, Neeraj Singh Gour   +5 more
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