Results 91 to 100 of about 541,947 (315)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Variations and trends in major research topics across leading general medical journals, 1966–2022

Critical Public Health
Attention to publication diversity calls for broader topic inclusion by journals. Although general medical journals have distinct editorial policies, cross-journal differences remain underexplored.
Nin-Chieh Hsu, Chia-Hao Hsu, Charles Liao, Yasuharu Tokuda   +3 more
doaj   +1 more source

Structuration sémantique des documents XML : Expérimentations et évaluation [PDF]

, 2014
National audienceLa norme XML permet la représentation d'un document selon un découpage logique qui ne reflète généralement pas la sémantique de son contenu. Il serait donc intéressant de compléter la structure logique des documents XML par une structure
Ben Meftah, Salma, Feki, Jamel, Khrouf, Kaïs, Soulé-Dupuy , Chantal   +3 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Development of a Taxonomy for Health Information Technology [PDF]

, 2007
Taxonomies provide schemas to help classify entities and define the relationships between them. Early computing enabled the development of ontologies and Medical Subject Headings (MeSH), the first modern classification of medical terminology as applied ...
Dixon, Brian E., McGowan, Julie J, Zafar, Atif   +2 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Automatic Category Recognition of MeSH Terms through Comparison of their Occurrence Frequency in Relevant and non-Relevant Documents

مدیریت اطلاعات سلامت, 2015
INTRODUCTION: Due to dynamic of terms, their classification is challenging. The current research aims at determining the usability of a model for automatic recognition of MeSH terms categories through measuring their occurrence frequency within relevant ...
Mohammad Tavakolizadeh-Ravari, Saeed Ghaffari, Forough Mostafavi   +2 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Gaps within the Biomedical Literature: Initial Characterization and Assessment of Strategies for Discovery

Frontiers in Research Metrics and Analytics, 2017
Within well-established fields of biomedical science, we identify “gaps,” topical areas of investigation that might be expected to occur but are missing. We define a field by carrying out a topical PubMed query and analyze Medical Subject Headings (MeSH)
Yufang Peng, Gary Bonifield, Neil R. Smalheiser   +2 more
doaj   +1 more source