Results 241 to 250 of about 4,286,167 (302)

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Medical Technology

Health Care Management Review, 1980
Technology was once considered automatically beneficial. Today the health care industry is carefully weighing the consequences as well as the advantages of medical technology. Medical technology has become a policy issue of great importance in public and private sectors.
D, Banta, C J, Behney
openaire   +2 more sources

Adopting Medical Technology

Medical Decision Making, 2014
New technologies are often incorporated into clinical practice with few data on their benefits and risks. In this issue of Medical Decision Making, Gold and colleagues report results of interviews with radiation oncologists and surgeons about factors that led to adoption of one treatment, accelerated partial breast irradiation (APBI).
openaire   +2 more sources

Evaluating Medical Technology

Annals of Internal Medicine, 1976
Excerpt Stross and colleagues, in this issue, report a carefully planned extension of coronary care units to small community hospitals of rural, sparsely settled northern Michigan.
openaire   +2 more sources

Patenting medical technology

Journal of Legal Medicine, 1990
(1990). Patenting medical technology. Journal of Legal Medicine: Vol. 11, No. 3, pp. 263-319.
openaire   +2 more sources

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