Results 21 to 30 of about 27,594 (209)

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

A scoping review of thresholds for responder and time‐to‐event analysis of patient‐reported outcomes in breast cancer trials

British Journal of Clinical Pharmacology, EarlyView.
Patient‐reported outcomes (PROs) are essential for assessing clinical benefit and tolerability from the patient's perspective. In oncology trials, PRO data analysis often involves responder and time‐to‐event analyses, which depend on predefined thresholds to determine clinically meaningful change.
Anna Margarete Maria Thurner, Daniela Krepper, Micha Johannes Pilz, Lisa Marie Storz, Maike Thumfart, Johannes Maria Giesinger   +5 more
wiley   +1 more source

Head and Neck Manifestations of Tularemia in Tyrol (Austria): A Case Series

Diagnostics
Background: Tularemia is a rare zoonosis caused by the bacterium Francisella tularensis. In the head and neck region, it can manifest as cervical lymphadenopathy.
Roland Hartl, Matthias Santer, Wegene Borena, Charles Schmit, Hannes Thomas Fischer, Daniel Dejaco, Benedikt Gabriel Hofauer, Teresa Bernadette Steinbichler   +7 more
doaj   +1 more source

The Cutaneous Branch of the Obturator Nerve: Common Finding or a Rarity Worthy of Note

Clinical Anatomy, EarlyView.
ABSTRACT According to textbook descriptions, branches of the femoral and obturator nerves provide the sensory innervation to the medial side of the thigh. However, as the exact prevalence of the obturator nerve's cutaneous branch is unknown, an anatomic study was conducted to reveal its role in providing cutaneous innervation to the medial thigh ...
Christoph Fuchssteiner, Theresia Stigger, Gerlinde M. Gruber, Peter. C. Brugger   +3 more
wiley   +1 more source

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

When governments act as strategists: Geopolitical turmoil and global strategy theory

Global Strategy Journal, EarlyView.
Abstract Research Summary The resurgence of geopolitical rivalry is challenging core assumptions of global strategy theory. Long‐standing views that economic interdependence is inherently beneficial, governments act as rule setters, multinational enterprises operate autonomously, and market and political strategy are separate no longer capture today's ...
Ari Van Assche, Thomas Lindner
wiley   +1 more source

A preliminary report of the dopamine receptor D4 and the dopamine transporter 1 gene polymorphism and its association with attention deficit hyperactivity disorder

Neuropsychiatric Disease and Treatment, 2008
Helmut Niederhofer1, Frauke Menzel2, Karl Göbel3, Brigitte Hackenberg4,5, Rainer Richter2,6, Maria Hildegard Walter2, Christian Gross7, Markus Huber8, Roger Pycha8, Hans-Jürgen Menzel9,101Ospedale Regionale di Bolzano, Via Guncina ...
Helmut Niederhofer, Frauke Menzel, Karl Göbel, Brigitte Hackenberg, Rainer Richter, et al   +5 more
doaj  

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Restoration of CPAK type in total knee arthroplasty does not lead to superior clinical outcome: A study based on arthroplasty registry data

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To assess the pre‐ and post‐operative distribution of patients undergoing total knee arthroplasty among the nine categories of the Coronal Plane Alignment of the Knee—CPAK classification (Aim 1). Another goal was to assess whether the clinical outcome (patient‐reported outcome and implant survival) differed between those whose CPAK ...
Michael Liebensteiner, Florian Pedross, Sabrina Neururer, Rohit Arora, Benedikt Koller, Martin Fischer, Michael Tobias Hirschmann, Paul Nardelli, Tyrol Arthroplasty Group, Kerstin Gruber, David Wippel, Nadine Kogler, Sebastian Ender   +12 more
wiley   +1 more source