Results 121 to 130 of about 7,992,354 (376)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Quantitative literacy provision in the first year of medical studies [PDF]

open access: yes, 2011
This is an Accepted Manuscript of an article published by Taylor & Francis in South African Journal of Higher Education in 2011, available online: http://reference.sabinet.co.za/sa_epublication_article/high_v25_n4_a7.This article presents a description ...
Frith, Vera
core  

Development and Validation of an Attitudinal-Profiling Tool for Patients With Asthma [PDF]

open access: yes, 2016
This study was supported and funded by Mundipharma Pte Ltd. Online survey and statistical analysis were performed by Pei-Li Teh, Rachel Howard, Tsin-Li Chua and Jie Sun of Research Partnership Pte Ltd. Medical writing support was provided by Sen-Kwan Tay
Aileen David-Wang   +7 more
core   +1 more source

Silodosin — a safer alpha-blocker targeting benign prostatic hyperplasia

open access: yesSouth African Family Practice, 2015
Silodosin is a specific alpha-1A receptor inhibitor newly available in South Africa. It offers a real solution to symptoms of BPH especially in those patients with moderate prostate enlargement experiencing nocturia, frequency and incomplete voiding.
Karen Koch
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Medice, Cura Te Ipsum (Physician, Heal Thyself): A Documentary Film Exploring How the Passions of Medical Students Will Make Them Better and Healthier Physicians [PDF]

open access: yes, 2019
It is a well documented, yet largely ignored fact that physicians, residents and medical students are experiencing a pandemic of depression, burnout, dissatisfaction, and suicide.
Emhoff, Ryan
core   +1 more source

Fostering Transformative Learning, Self-reflexivity and Medical Citizenship Through Guided Tours of Disadvantaged Neighborhoods [PDF]

open access: yes, 2018
Background and objectives: Medical school curricula increasingly seek to promote medical students’ commitment to redressing health disparities, but traditional pedagogical approaches have fallen short of this goal.
Brooks, E. Marshall   +2 more
core   +2 more sources

Benveniste’s Experiments Explained by a Non-Conventional Experimenter Effect

open access: yesMedicines, 2018
Background: Benveniste’s biology experiments suggested the existence of molecular-like effects without molecules (“memory of water”). In this article, it is proposed that these disputed experiments could have been the consequence of a previously ...
Francis Beauvais
doaj   +1 more source

THE WRITING OF MEDICAL PAPERS [PDF]

open access: yesThe American Journal of the Medical Sciences, 1922
n ...
openaire   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

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