Results 121 to 130 of about 3,439,907 (351)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Reducing Quotation Errors in Scientific Manuscripts: A Novel Approach from the Global Andrology Forum

The World Journal of Men's Health
Purpose: This study investigated 1) the frequency of quotation errors in multi-authored medical manuscripts in andrology, 2) analyzed common types of quotation errors and the methods used to rectify them, and 3) evaluated their impact on manuscript ...
Asli Metin Mahmutoglu, Ashok Agarwal, Bahadir Sahin, Tomer-Avidor Reiss, Pallav Sengupta, Germar-Michael Pinggera, Hiva Alipour, Rossella Cannarella, Christine Wyns, Mohamed Arafa, Aldo E. Calogero, Taymour Mostafa, Eric Chung, Ala’a Farkouh, Ahmad Motawi, Amarnath Rambhatla, Ayad Palani, Giovanni M. Colpi, Murat Gül, Selahittin Çayan, Israel Maldonado Rosas, Taha Abo-Almagd Abdel-Meguid Hamoda, Rupin Shah   +22 more
doaj   +1 more source

Revision Strategies

Southwest Respiratory and Critical Care Chronicles, 2016
Revision is difficult for many writers. This article outlines a systematic approach to revision, including concrete strategies for addressing both higher-order concerns and lower-order concerns.
Kristin Messuri
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Les traités sur les eaux de Barèges de Christopher Meighan (1742, 1764) : Que faire des « cas » ?

Histoire, Médecine et Santé
This article examines two editions of British physician Christopher Meighan’s treatise on the waters of Barèges (1742 and 1764), exploring how medical cases were used both as tools for formalizing knowledge and as a source for writing the history of ...
Sophie Vasset, François Zanetti
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The evolution of ChatGPT-generated text in scientific medical publications

Saudi Journal of Anaesthesia
Background: ChatGPT is an Artificial intelligence (AI) language model that enhances readability in medical writing. However, the prevalence of ChatGPT-generated articles in English medical literature has not been systematically studied.
Fuat H. Saner, Roman Schumann, Leen Alchibi, Sami A. Kareem, Kris Ann H. Marquez, Yasemin M. Saner, Ehab Abufarhaneh, Dieter C. Broering, Dimitri A. Raptis, The HeALgroup.AI Collaborative (Appendix)   +9 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source