Results 161 to 170 of about 16,778 (296)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Breaking psychedelic boundaries in public health: emerging ideas with ancient roots. [PDF]

Front Public Health
Bartlett K, Gezon LL, Ward WD, Sears F.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Medicalization and Masculinities

Kvinder, Køn & Forskning, 2020
Karen Hvidtfeldt, Camilla Bruun Eriksen, Michael Nebeling Petersen, Kristian Møller, Sebastian Mohr, Anna Sofie Bach, Sheila L. Cavanagh, Eli Smeplass, Bent Olsen, Camilla Tved   +9 more
doaj   +1 more source

Barriers and facilitators to deprescribing in primary care in Brazil: a qualitative study of pharmacists' perspectives mapped to the Theoretical Domains Framework. [PDF]

Geriatr Gerontol Aging
de Melo MF, Castro PR, Pinheiro RM, Steinman MA, Wachholz PA, Oliveira MG.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Power without limits: exploring emotional regulation, moral authority, and psychiatric overreach through the <i>Wizarding World</i> of <i>Harry Potter</i>. [PDF]

Front Psychiatry
Torales J, Estigarribia G, Barrios I, O'Higgins M, Sosa Gamarra AJ, Da Silva Sánchez FI, Castaldelli-Maia JM, Ventriglio A.   +7 more
europepmc   +1 more source

Changing ideas: The medicalization of menopause

This paper examines the intellectual roots of the medicalization of menopause in the 1930s and 1940s. An analysis of published papers written by prominent American medical specialists reveals three models that were developed to understand menopause ...
Bell, Susan E.
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Ozempic and Wegovy Meet Congress: Political Economy Without Critique and Sociology Without Society. [PDF]

Int J Soc Determinants Health Health Serv
Loeppky R.
europepmc   +1 more source