Results 211 to 220 of about 5,181,983 (378)

Medical Education and Medical Migration [PDF]

Proceedings of the Royal Society of Medicine, 1970
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Is Assisted Dying Really a Matter for Medical Regulation? [PDF]

J Law Med Ethics
Hardes Dvorak J.
europepmc   +1 more source

Non-medical use of opioid analgesics in contemporary Brazil: Findings from the 2015 Brazilian National Household Survey on Substance Use

, 2019
Noa Krawczyk, Pedro Luís do Nascimento Silva, Raquel B. De Boni, Jurema Corrêa da Mota, Mauricio Vascncellos, Neilane Bertoni, Carolina Coutinho, Francisco Inácio Bastos   +7 more
openalex   +2 more sources

Medical Conferences and Medical Practice

Journal of Orthopaedic Diseases and Traumatology, 2023
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Profiles of palliative day care programs in Canada and the United Kingdom: A meta-synthesis. [PDF]

Palliat Care Soc Pract
Fortin G, Leblanc-Huard G, Kernohan G, Hasson F.   +3 more
europepmc   +1 more source

Interactive Session for Residents and Medical Students on Dermatologic Care for Lesbian, Gay, Bisexual, Transgender, and Queer Patients

, 2021
Devon Barrett, Krittin J. Supapannachart, Ramoncito L. Caleon, Laura Ragmanauskaite, Patrick E. McCleskey, Howa Yeung   +5 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Rethinking medicalization: unequal relations, hegemonic medicalization, and the medicalizing dividend. [PDF]

Theory Soc
Halpin M, Cortez D.
europepmc   +1 more source