Results 61 to 70 of about 5,181,983 (378)

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

‘From Badness to Sickness’ and Back Again: The Use of Medication in the U.S. School and Foster Care Systems [PDF]

open access: yes, 2018
This article explores the over- and under-prescription of psychotropic medication to youth of color both in public schools and the foster care system. Under the umbrella of the schools-to-prison pipeline, there is a wide array of literature addressing ...
Nemetz, Sarah J.
core   +1 more source

Psychiatrization in mental health care: The emergency department

open access: yesFrontiers in Sociology, 2022
BackgroundIn the light of high incidences of diagnosed mental disorders and the growing utilization of mental healthcare services, a progressing psychiatrization of society has been hypothesized as the underlying dynamic of these developments.
Timo Beeker
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

The Historical Evolution of the Medicalization of Children's Attention Deficit Hyperactivity Disorder

open access: yesYixue yu zhexue
Children attention deficit hyperactivity disorder (ADHD) is a classic case in the field of medicalization research, highlighting the expansion of medicine into the realm of daily life.
Weiyu LI, Shu WEI
doaj   +1 more source

Medicalization – A growing problem

open access: yesJournal of the Scientific Society, 2019
Medicalization is the latest growing trend of our modern society. The Western scholars have debated for decades about its merits and demerits. Medical profession has always been blamed for the medicalization, but there are also other factors that ...
Sajid Hameed
doaj   +1 more source

Exploring Biomedical, Temporal, and Embodied Perspectives on the Timing of Birth in Central Nepal [PDF]

open access: yes, 2018
As an ANHS Senior Fellow, I began to explore the standardization of time in obstetrics and its translation into everyday practice in Nepal by analyzing the various perspectives involved in determining a woman’s ideal time of delivery and a successful ...
Brunson, Jan, Tamrakar, Suman Raj
core   +3 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

[Social practices in the medicalization and humanization of prenatal care].

open access: yesCadernos de Saúde Pública, 2018
The study's main objective is to analyze how discourses of medicalization and humanization reconnect in primary healthcare and shape prenatal care for pregnant women provided by family health teams.
Cristine Maria Warmling   +3 more
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

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