Results 81 to 90 of about 6,531 (261)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

“NIEWIADOMOŚĆ [...] NIE JEST OBŁĘDEM”. O LISTACH MARII KOMORNICKIEJ DO MATKI

open access: yesPl.it, 2021
This paper focuses on the letters (starting in 1907) that Maria Komornicka addressed to her mother, written from the psychiatric and mental institutions where she was confined. Notably, in these writings the first- person voice is a male subject.
Urszula Kowalczuk
doaj  

Discontinuance of ADHD Treatment in Adolescents

open access: yesPediatric Neurology Briefs, 2009
Prevalence of ADHD drug discontinuance in adolescents and young adults was studied in the UK by using the General Practice Database for patients aged 15-21 years from 1999 to 2006.
J Gordon Millichap
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Rethinking medicalization: discursive positions of children and their caregivers on the diagnosis and treatment of ADHD in Chile

open access: yesSaúde e Sociedade
The debates around the diagnosis and pharmacological treatment of Attention Deficit and Hyperactivity Disorder (ADHD) have traditionally been approached from the perspective of the “medicalization processes” of children’s behaviour.
Pablo Reyes   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Health and Social Issues from the Perspective of Medicalization of Society: Zola's Pioneering Contributions

open access: yesYixue yu zhexue
In the 1970s, Irving Kenneth Zola, a pioneer of contemporary medical criticism, proposed the concept of "the medicalization of society", which systematically revealed how modern medicine surpassed traditional diagnostic and therapeutic functions and ...
Wenpei TANG, Xun ZHOU
doaj   +1 more source

Medykalizacja kobiecego ciała na przykładzie operacji plastycznych

open access: yesScientia et Fides, 2013
Medykalizacja człowieka, w tym także dyskutowana w ramach poniższego tekstu medykalizacja kobiecego ciała z użyciem chirurgii kosmetycznej, mimo szerokiego wachlarza deklarowanych przez naukowców korzyści, bezspornie implikuje mnogość problemów natury ...
Marcin Leźnicki
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

How French media have portrayed ADHD to the lay public and to social workers

open access: yesInternational Journal of Qualitative Studies on Health & Well-Being, 2017
Two models of attention deficit hyperactivity disorder (ADHD) coexist: the biomedical and the psychosocial. We identified in nine French newspapers 159 articles giving facts and opinions about ADHD from 1995 to 2015.
Sébastien Ponnou, François Gonon
doaj   +1 more source

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