Results 81 to 90 of about 5,089,335 (341)
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Soulager les douleurs de femmes lors de l’accouchement
Genre, Sexualité et Société, 2016 In France, 80 % of women that are giving birth use epidural anesthesia. However, not everyone agrees on such medicalization of the childbirth-related pain’s alleviation.
Maud Arnal
doaj +1 more source
Medical Education and Medical Reform [PDF]
, 1995 Au XIX e siecle, l'enseignement medical a subi quelques reformes afin de centrer davantage l'enseignement a l ...
openaire +3 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Medykalizacja kobiecego ciała na przykładzie operacji plastycznych
Scientia et Fides, 2013 Medykalizacja człowieka, w tym także dyskutowana w ramach poniższego tekstu medykalizacja kobiecego ciała z użyciem chirurgii kosmetycznej, mimo szerokiego wachlarza deklarowanych przez naukowców korzyści, bezspornie implikuje mnogość problemów natury ...
Marcin Leźnicki
doaj +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Discontinuance of ADHD Treatment in Adolescents
Pediatric Neurology Briefs, 2009 Prevalence of ADHD drug discontinuance in adolescents and young adults was studied in the UK by using the General Practice Database for patients aged 15-21 years from 1999 to 2006.
J Gordon Millichap
doaj +1 more source
MEDICAL DISCOVERIES BY THE NON-MEDICAL. [PDF]
JAMA: The Journal of the American Medical Association, 1903 I have been struck by the fact that the majority of great medical discoveries, truths and instruments, have not been made completely and suddenly, but have been led up to by preliminary and progressive steps, and that the layman has so often made these discoveries prior to the medical practitioner.
openaire +2 more sources
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source