Results 181 to 190 of about 6,860,665 (269)

Evaluating the Efficacy of Cytokine‐Directed Therapies in the Management of VEXAS Syndrome

ACR Open Rheumatology, Volume 8, Issue 10, October 2026.
Objective To evaluate the efficacy of cytokine‐directed therapies in VEXAS (vacuoles, E1 enzyme, X‐linked, autoinflammatory somatic) syndrome using previously proposed treatment response criteria. Methods All patients with genetically confirmed VEXAS syndrome who received targeted therapies with JAK inhibitors (JAKi), tumor necrosis factor α inhibitors
Daniel Montes, Hannah E. Langenfeld, Andrew C. Hanson, Cynthia S. Crowson, Mrinal M. Patnaik, Ronald S. Go, Kambiz Kalantari, Yael Kusne, Terra Lasho, Abhishek A. Mangaonkar, Horatiu Olteanu, Kaaren K. Reichard, Megan M. Sullivan, David S. Viswanatha, Kenneth J. Warrington, Matthew J. Koster   +15 more
wiley   +1 more source

Quality of Life in Adults With Metastatic Breast Cancer: The Impact of Between‐ and Within‐Person Changes in Symptoms and Positive Affect

Cancer Medicine, Volume 15, Issue 10, October 2026.
Individuals living with metastatic breast cancer experienced substantial within‐person and between‐person variations in symptom severity and positive affect, which affected their quality of life. These data highlight the need for adaptive, targeted intervention strategies to optimize quality of life for all patients.
Brenna Mossman, Brent J. Small, Elizabeth L. Addington, Judith Tedlie Moskowitz, Mikaela A. Velazquez‐Sosa, Jennifer D. Rodriguez, Aigner Bobbitt, Alene Mathurin, Lesley Glenn, Shontè Drakeford, Roxana Guerra, Claudine Isaacs, Ami Chitalia, Christopher Gallagher, Deena Graham, Nina Kadan‐Lottick, Suzanne C. O'Neill, Claire C. Conley   +17 more
wiley   +1 more source

Cavitary Pulmonary Adenocarcinoma in a Young Adult With a History of Treated Hodgkin Lymphoma: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Cavitary lung lesions are commonly attributed to infection; however, malignancy should remain a diagnostic consideration. We report a 30‐year‐old non‐smoking man with a history of treated Hodgkin lymphoma who presented with a cavitary pulmonary adenocarcinoma. This case highlights the importance of considering rare malignant causes.
Hosam Aldalbahi, Nora Ahmed Bedaiwi
wiley   +1 more source

A Novel Homozygous Frameshift Variant in ZNF699 Associated With DEGCAGS Syndrome With Severe Transfusion‐Dependent Anemia in an Indian Child: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT In children with unexplained multisystem involvement—global developmental delay, dysmorphism, skeletal anomalies, and severe transfusion‐dependent anemia—especially from consanguineous families, whole‐exome sequencing should be pursued early to enable timely diagnosis, proactive iron chelation, and genetic counseling.
Arimanda Chaitanya Laasya Reddy, A. Vamshee Priya, Aditya Pachwa, Boilla Abhignya Reddy, Lakshya Nehal Samineni, Lanka Gourav Reddy   +5 more
wiley   +1 more source

Hypertriglyceridemic Acute Pancreatitis With Concomitant Retrocecal Appendicitis: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Hypertriglyceridemia‐induced acute pancreatitis and acute appendicitis are distinct clinical conditions rarely reported to occur concurrently. We present a case of hypertriglyceridemia‐induced pancreatitis characterized by clinical deterioration despite a decline in serum triglyceride levels.
Mansoureh Shekarchizadeh Esfahani, Masood Shekarchizadeh, Seyed Amirhossein Dormiani Tabatabaei, Mehrnazsadat Dormiani Tabatabaei   +3 more
wiley   +1 more source

Identifying Treatment Modalities for a Multidisciplinary and Blended Care Intervention for Patients With Moderate Medically Unexplained Physical Symptoms: Qualitative Study Among Professionals. [PDF]

JMIR Ment Health, 2019
van Westrienen PE, Pisters MF, Gerrits M, Veenhof C, de Wit NJ.   +4 more
europepmc   +1 more source

Unusual Hemodynamic Presentation of Pediatric Kikuchi‐Fujimoto Disease: Persistent Sinus Bradycardia and Vasopressor‐Dependent Hypotension

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Kikuchi‐Fujimoto disease rarely presents with vasopressor‐dependent hypotension requiring pediatric intensive care despite preserved cardiac function. This case highlights the importance of early excisional lymph node biopsy for timely diagnosis and appropriate management of children with unexplained hemodynamic instability and necrotizing ...
Abdulla Alfraij, Fatma Mothafar, Wasmi Alfadhli, Ali Ashkanani, Lujain A. Kamal, Esmail Redha, Abdulrahman Aldaithan   +6 more
wiley   +1 more source

Clinical practitioners' views on the management of patients with medically unexplained physical symptoms (MUPS): a qualitative study. [PDF]

BMJ Open, 2016
Brownell AK, Atkins C, Whiteley A, Woollard RF, Kornelsen J.   +4 more
europepmc   +1 more source

Anti‐U1‐RNP‐Positive Inflammatory Myopathy Presenting With Dysphagia: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT High‐titer anti‐U1‐RNP antibodies may present with myopathy without fulfilling MCTD criteria. We report a 38‐year‐old woman with proximal weakness, elevated muscle enzymes, anti‐U1‐RNP positivity, and inflammatory myopathy on EMG/MRI, but lacking classic overlap features.
Anjlee, Sana Rasheed, Moosa Ashfaq, Simran Bai, Ali Jan Yaqubi, Ahmed Asad Raza   +5 more
wiley   +1 more source

Magnetic resonance imaging‐based meniscal coverage and cartilage thickness are associated with mechanical axis alignment in knee osteoarthritis

Journal of Experimental Orthopaedics, Volume 13, Issue 4, October 2026.
Abstract Purpose This study examined whether magnetic resonance imaging (MRI)‐based meniscal and cartilage measurements explain the percentage of mechanical axis (%MA) to a degree comparable with the joint line convergence angle (JLCA) when added to the arithmetic hip–knee–ankle (aHKA) angle.
Atsushi Sasabe, Nobutake Ozeki, Hisako Katano, Yusuke Nakagawa, Tomomasa Nakamura, Hideyuki Koga, Ichiro Sekiya   +6 more
wiley   +1 more source