Results 41 to 50 of about 68,643 (224)

ANÁLISE DO CIPROFLOXACINO EM AMOSTRAS DE MEDICAMENTOS DE REFERÊNCIA, SIMILAR E GENÉRICO POR ESPECTROSCOPIA NO INFRAVERMELHO

Revista Univap, 2016
O ciprofloxacino é um antibiótico ativo contra bactérias gram negativas e indicado para infecções do trato urinário, prostatites, gastroenterites severas, doenças sexualmente transmissivéis (DSTs), infecções da pele e tecidos moles, não indicado em Pneumonias por S. pneumoniae.
Caroline Aparecida Lima, Rafael Viana Toledo, Kumiko Koibuchi Sakane   +2 more
openaire   +4 more sources

Influence and convergence to higher standards: The dual examination of pharmaceutical patents in Brazil

The Journal of World Intellectual Property, EarlyView.
Abstract Between 2001 and 2021, pharmaceutical patent applications filed in Brazil were examined by the patent office (INPI) and the national health regulator (Anvisa). This paper investigates how health regulators can contribute to patent examination by shifting the set of criteria cited as grounds for 2589 negative decisions from both entities ...
Eduardo Mercadante
wiley   +1 more source

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1650-1661, June 2026.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

ESTUDO ANALÍTICO E COMPARATIVO DE COMPRIMIDOS CONTENDO CITRATO DE SILDENAFILA ADQUIRIDOS NO MERCADO FORMAL E INFORMAL

Infarma: Pharmaceutical Sciences, 2016
Citrato de sildenafila é um fármaco inibidor seletivo da enzima fosfodiesterase tipo 5 (PDE-5), restaurando naturalmente a função erétil peniana. O objetivo deste estudo foi realizar uma análise comparativa do aspecto visual, peso médio e uniformidade de
Jonathan Parisotto Peterle, Francie Bueno   +1 more
doaj   +1 more source

Características de la gestión clínica y aspectos de la terapéutica farmacológica en pacientes con enfermedades cardiovasculares de un hospital nivel III de Lambayeque 2014-2015 : estudio preliminar [PDF]

, 2019
Describir las características de la gestión clínica y aspectos de la terapéutica farmacológica de los pacientes con enfermedades cardiovasculares en un hospital nivel III 2014-2015. Métodos y Materiales: Estudio descriptivo transversal.
Parraguez Mendoza, Cecilia del Socorro
core   +1 more source

Clinical Factors Associated With Current Relevance in Allergic Contact Dermatitis: Development of Predictive Models Based on Data From the Spanish Contact Dermatitis Register (REIDAC)

Contact Dermatitis, Volume 94, Issue 6, Page 614-623, June 2026.
This study has shown a moderate performance of the regression model to predict current relevance (AUC = 0.679), although modelling performance has been better for specific allergens (e.g., nickel with an AUC = 0.770). Furthermore, it has identified key predictors, including female gender, specific involved sites (hands, neck, head, legs, feet), and ...
David Pesqué, Francisco Javier Ortiz de Frutos, Francisco Navarro‐Triviño, Tatiana Sanz‐Sánchez, Violeta Zaragoza‐Ninet, Susana Córdoba‐Guijarro, Javier Miquel‐Miquel, Juan Francisco Silvestre‐Salvador, Ricardo González‐Pérez, Inmaculada Ruiz‐González, Pedro Mercader‐García, Esther Serra‐Baldrich, José Manuel Carrascosa‐Carrillo, Fátima Tous‐Romero, Mercedes Rodríguez‐Serna, María Elena Gatica‐Ortega, Carmen Paredes‐Suárez, María Antonia Pastor‐Nieto, Pablo Chicharro, Marta Andreu, Araceli Sánchez‐Gilo, José Juan Pereyra‐Rodríguez, Gemma Melé‐Ninot, Paloma Sánchez‐Pedreño Guillén, Enrique Gómez de la Fuente, Marta Elosua‐González, Fernando Gallardo, Ramon M. Pujol, Ignacio García‐Doval, Leopoldo Borrego, Miguel Ángel Descalzo, Ana M. Giménez‐Arnau   +31 more
wiley   +1 more source

Farmacovigilância no Brasil: a relação entre polimorfismo de fármacos, efetividade e segurança dos medicamentos

Revista de Ciências Farmacêuticas Básica e Aplicada, 2008
Apesar da política nacional de medicamentos propor que os mesmos tenham qualidade, eficácia e segurança, os hospitais sentinelas têm recebido notificações de queixa técnica, reações adversas e suspeita de inefetividade terapêutica de medicamentos.
H.C. Capucho, P.C. Mastroianni, S.R.A. Cuffini   +2 more
doaj  

Low‐intervention clinical trials in Spain: Do they progress?

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1438-1444, May 2026.
Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza, Mayro J. Cortés Pestana, Kristopher Amaro, Rosa M. Antonijoan, Caridad Pontes   +4 more
wiley   +1 more source

La identificación de “los deportistas clientes” en los delitos de dopaje deportivo bajo la modalidad de autotransfusión sanguínea [PDF]

, 2016
This study analyzes the problems of blood autotransfusion of athletes in cases connected with doping offenses in sport, based on the spanish controversial case “Operación Puerto”.
Mendoza Calderón, Silvia
core   +2 more sources

Actionable Pharmacogenomics and Essential Medicines: An Analysis of WHO and African Lists for Safer and Efficacious Drug Use

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1371-1381, May 2026.
The World Health Organization Model Essential Medicines List and African national essential medicines lists (EMLs) detail drugs intended to be consistently available within national health systems, thereby supporting clinicians and pharmacists in making evidence‐based treatment decisions.
Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Janine Scholefield, Collen Masimirembwa   +5 more
wiley   +1 more source