Results 71 to 80 of about 73,929 (196)

Establishment and evaluation of a risk prediction model for venlafaxine plasma concentration exceeding alert levels

Precision Medication
Objective: To investigate the factors influencing venlafaxine blood concentration exceeding the alert threshold in patients with depression and to develop a risk prediction model for elevated venlafaxine concentrations, providing a reference for ...
Yanjing Zhang, Chunhua Zhou, Xiaodong Li, Yan Liu, Jing Wang, Jing Yu   +5 more
doaj   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Integrative multi-omics approach for drug repositioning in Alzheimer's disease

Precision Medication
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an insidious onset, and effective therapeutic agents are urgently needed. Objective: This study employed a multi-omics integration strategy for drug repurposing against
Jinna Yang, Kaimin Guo, Xiaxia Ren, Xiaolian Zhang, Shuang Zhao, Jiansong Fang, Yu Wei, Pengcheng Yang, Wenjia Wang, Hui Wang, Yunhui Hu   +10 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A retrospective study on the impact of glucocorticoids on the efficacy of posaconazole in the prevention/treatment of invasive fungal infections in patients with hematological malignancies

Precision Medication
Background: Posaconazole (PCZ) has been used to prevent and treat invasive fungal infections in immunocompromised patients with hematological malignancies.
Shizhao Yuan, Shuai Liu, Yan Zhao, Ziyi Wang, Yan Liu, Jing Yu   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Effects of donepezil on emotion, cognitive function, and inflammatory factors in patients with Hashimoto's thyroiditis

Precision Medication
Objective: To investigate the impact of donepezil on emotional responses, cognitive function, and inflammatory factors in patients with Hashimoto's thyroiditis (HT).
Chengwu Wang, Xuelian Jiang, Xiumei Sun, Wenlu Guo, Fen Wang, Defa Zhu   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Surgical pharmacy for catalyzing pharmacy service throughout surgical continuum

Precision Medication
The greater the complementarity between pharmacists’ knowledge and doctors’ knowledge, the more significant the role pharmacists can play in clinical practice. Physicians extensively use drugs for disease management and are well-versed in the medications
Zhihua Zheng
doaj   +1 more source