Results 41 to 50 of about 528,791 (356)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

DRUG ADMINISTRATION: A SYSTEMIC VIEW FOR THE DEVELOPMENT OF MEDICATION ERROR PREVENTIVE ACTIONS [PDF]

Revista Eletrônica de Enfermagem, 2004
The drug administration is a very frequent activity of a hospital routine in general, as well as of itsnursing team. However studies have shown the need to implement strategies to prevent or to mitigate errors foundin this pratice.
Silvia Helena De Bortoli Cassiani, Ana Elisa Bauer de Camargo Silva   +1 more
doaj  

Can the Heinrich ratio be used to predict harm from medication errors? [PDF]

, 2006
The purpose of this study was to establish whether, for medication errors, there exists a fixed Heinrich ratio between the number of incidents which did not result in harm, the number that caused minor harm, and the number that caused serious harm.
Barber, N, Franklin, BD, Gallivan, S, Taxis, K   +3 more
core  

Strategies to reduce medication errors with reference to older adults [PDF]

, 2006
Background  In Australia, around 59% of the general population uses prescription medication with this number increasing to about 86% in those aged 65 and over and 83% of the population over 85 using two or more medications simultaneously. A recent report
Adams C, Aufseeser Weiss MR, Australian Council for Safety and Quality in Health Care., Australian Institute of Health and Welfare (AIHW)., Australian Institute of Health and Welfare., Ayuthya S, Bates DW, Bayne T, Bolton P, Boyle CM, Brent Hodgkinson, Briggs B, Brown HN, Brown SJ, Burton ME, Casner PR, Cerne F, Hawkey CJ, Heinemann D, Hurley SF, Khan KS, Kim Nichols, Kruse H, Larrabee JH, Leape LL, Lengacher CA, Ludwig Beymer P, McNally KM, Mungall DR, Mutter M, Nelson R, NHMRC., Overhage JM, Papastrat K, Pape TM, Ray MD, Rhonda Nay, Roark DC, Roughead EE, Schaubhut RM, Shah NR, Shojania KG, Spencer DC, Strohecker S, Susan Koch, Westwood M, White RH   +46 more
core   +1 more source

Medication errors [PDF]

Nurse Prescribing, 2018
In its report of the Short Life Working Group on reducing medication-related harm, the Department of Health and Social Care (DHSC) (2018) provided a UK response to the World Health Organization's (WHO) (2017) Global Patient Safety Challenge, ‘Medication without Harm’. WHO (2017) recognised that there is significant harm caused to patients globally as a
openaire   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Are We Making Smart Pumps Smarter? [PDF]

, 2018
Background: Medication errors comprise a significant proportion of medical errors, and are abundant, costly, and associated with causing harm to patients via adverse drug events. The most serious medication errors often involve IV medications.
Schaefer, Brittany
core   +1 more source

The effect of individual factors on the medication error [PDF]

, 2016
Medication error is a major issue in healthcare industry and significant efforts have been taken in recent years to comprehend factors that influence errors in medication.Therefore, the present study aims to examine individual factors that contribute to ...
Chew Abdullah, Nor Azimah, Zyoud, Amr H.
core   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

MEDICATION ERRORS: A PROSPECTIVE STUDY IN MOHAMED V MILITARY TEACHING HOSPITAL, RABAT, MOROCCO

Journal of Community Medicine and Public Health Research, 2022
Medication errors (MEs) are preventable events that may cause or lead to inappropriate medication use or patient harm. Annually 98,000 patients die because of avoidable MEs, and it is considered a financial burden on public health organizations.
Youssef Moutaouakkil, Zouhair El Allali, Samira Serragui, Mina Ait El Cadi, Jamal Lamsaouri, Rachid El Jaoudi, Yassir Bousliman   +6 more
doaj   +1 more source