Results 51 to 60 of about 370,533 (353)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Medication errors in the Middle East countries: a systematic review of the literature [PDF]

, 2012
Background: Medication errors are a significant global concern and can cause serious medical consequences for patients. Little is known about medication errors in Middle Eastern countries.
A Aldhawailie, A Ben-Yehuda, A Drach-Zahavy, A Elnour, A Jiménez Muñioz, A Kazemi, A Kazemi, A Lifshitz, A Lustig, A Oliven, A Oliven, A Vardi, B Bar-Oz, B Dean, B Dean, B Dean, B Franklin, D Cousins, E Allan, E Kozer, E O’Shea, E Tissot, F Fahimi, F Fahimi, F Valizadeh, G Armitage, G Kadmon, G Vessal, H Alagha, H Dibbi, H Khalili, H Koohestani, H Koohestani, H Koohestani, I Choonara, Imti Choonara, International Diabetes Federation, J Islamian, J Osborne, K Alkhaja, K Alkhaja, K Alkhaja, K Khaja, L Azoulay, M Aljeraisy, M Alshara, M Ghaleb, M Lisby, M Magzoub, M Miller, M Mrayyan, M Sadat-Ali, M Schneider, N Abou alsoud, N Greengold, N Qureshi, N Sabry, National Patient Safety Agency, O Vaknin, P Lewis, R Hooper, S Conroy, S Conroy, S Joolaee, Sharon Conroy, T Khoja, T Lesar, U Nations, V Wirtz, W Sweileh, Y Irshaid, Y Neyaz, Y Saab, Zayed Alsulami   +73 more
core   +3 more sources

Effects of stratified medication review in high-risk patients at admission to hospital: a randomised controlled trial

Therapeutic Advances in Drug Safety, 2020
Background: Patients at high risk of medication errors will potentially benefit most from medication reviews. An algorithm, MERIS, can identify the patients who are at highest risk of medication errors. The aim of this study was to examine the effects of
Dorthe Krogsgaard Bonnerup, Marianne Lisby, Eva Aggerholm Sædder, Birgitte Brock, Tania Truelshøj, Charlotte Arp Sørensen, Anita Gorm Pedersen, Lars Peter Nielsen   +7 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Frequency and types of the medication errors in an academic emergency department in Iran: The emergent need for clinical pharmacy services in emergency departments

Journal of Research in Pharmacy Practice, 2013
Objective: Emergency departments (EDs) are characterized by simultaneous care of multiple patients with various medical conditions. Due to a large number of patients with complex diseases, speed and complexity of medication use, working in under-staffing
Alireza Zeraatchi, Mohammad-Taghi Talebian, Amir Nejati, Simin Dashti-Khavidaki   +3 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Patient safety in Europe: medication errors and hospital-acquired infections [PDF]

, 2008
The Report was commissioned by the European Federation of Nurses Associations (EFN) in November 2007 in order to support its policy statements on Patient Safety (June 2004).
Burke, J., Smith, L.N., Sveinsdóttir, H., Willman, A.   +3 more
core   +1 more source

Errors and discrepancies in the administration of intravenous infusions: a mixed methods multihospital observational study [PDF]

, 2018
Introduction Intravenous medication administration has traditionally been regarded as error prone, with high potential for harm. A recent US multisite study revealed few potentially harmful errors despite a high overall error rate.
Bates, David W., Blandford, Ann, Chumbley, Gillian, Cox, Anna, Dykes, Patricia C., Franklin, Bryony Dean, Furniss, Dominic, Galal-Edeen, Galal H., Iacovides, Ioanna, Lyons, Imogen, Mayer, Astrid, Schnock, Kumiko O., Vos, Jolien, Wei, Li   +13 more
core   +3 more sources

Medication incidents related to technology in a University-affiliated general hospital in 2006-2010 [PDF]

, 2012
Oral Presentations - Drug safety and Toxicology: no. C010INTRODUCTION: Technology often helps to reduce medication errors. The objective of this study was to assess medication errors in relation to technology used in the prescription or administration of
Cheung, BMY, Chui, CMW, Samaranayake, NR
core   +3 more sources

Duplication errors due to brand name confusion; It is not always the name—Short case series

Clinical Case Reports, 2023
Key Clinical Message Confusion of drug names has been identified as a leading cause of medication errors and potential iatrogenic harm. Most of these errors occur because of look‐alike or sound‐alike drugs.
N. Mamunuwa, S. Jayamanne, N. Wijekoon, J. Coombes, D. Perera, T. Shanika, F. Mohamed, C. Lynch, A. De Silva, A. Dawson   +9 more
doaj   +1 more source