Results 81 to 90 of about 2,458,624 (375)

Evaluating diversion and treatment policies for opioid use disorder [PDF]

arXiv, 2023
The United States (US) opioid crisis contributed to 81,806 fatalities in 2022. It has strained hospitals, treatment facilities, and law enforcement agencies due to the enormous resources and procedures needed to respond to the crisis. As a result, many individuals who use opioids never receive or finish the treatment they need and instead have many ...
arxiv  

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Enhancing Use of Medications for Opioid Use Disorder Through External Coaching

Psychiatric Services, 2023
This randomized controlled trial tested whether external coaching influences addiction treatment providers' utilization of medications to treat opioid use disorder (MOUDs).This study recruited 75 unique clinical sites in Florida, Ohio, and Wisconsin, including 61 sites in specialty treatment agencies and 14 behavioral health sites within health systems.
Molfenter, Todd, Kim, Hanna, Kim, Jee-Seon, Kisicki, Abby, Knudsen, Hannah K, Horst, Julie, Brown, Randy, Madden, Lynn M, Toy, Alex, Haram, Eric, Jacobson, Nora   +10 more
openaire   +4 more sources

Equitable Data-Driven Facility Location and Resource Allocation to Fight the Opioid Epidemic [PDF]

arXiv, 2023
The opioid epidemic is a crisis that has plagued the United States (US) for decades. One central issue is inequitable access to treatment for opioid use disorder (OUD), which puts certain populations at a higher risk of opioid overdose. We integrate a predictive dynamical model and a prescriptive optimization problem to compute high-quality opioid ...
arxiv  

Locus Coeruleus Noradrenergic‐Spinal Projections Contribute to Electroacupuncture‐Mediated Antinociception in Postoperative Pain in Mice

Advanced Science, EarlyView.
How locus coeruleus noradrenergic‐spinal projections and subsequent α2A adrenoceptors‐CaMKII signaling cascades contribute to electroacupuncture‐induced antinociception in postoperative pain in mice is described. Abstract Postoperative pain remains a significant challenge in healthcare.
Wen‐Guang Chu, Ru Zhang, Hai‐Tao Li, Ying‐Chun Li, Hui Ding, Zhen‐Zhen Li, Wen‐Juan Han, Fei Wang, Xing‐Xing Zheng, Hong‐Hui Mao, Hua Yuan, Sheng‐Xi Wu, Rou‐Gang Xie, Ceng Luo   +13 more
wiley   +1 more source

Availability of best practices for opioid use disorder in jails and related training and resource needs: findings from a national interview study of jails in heavily impacted counties in the U.S.

Health & Justice, 2022
Background Jails are optimal settings in which to screen individuals for opioid use disorders (OUD) and provide needed services, especially medications for OUD (MOUD).
Christy K. Scott, Christine E. Grella, Michael L. Dennis, John Carnevale, Robin LaVallee   +4 more
doaj   +1 more source

Treatment and Prevention of Opioid Use Disorder: Challenges and Opportunities [PDF]

, 2017
Treatment for opioid use disorder in the United States evolved in response to changing federal policy and advances in science. Inpatient care began in 1935 with the US Public Health Service Hospitals in Lexington, Kentucky, and Fort Worth, Texas ...
Korthuis, P. Todd, McCarty, Dennis, Priest, Kelsey C.   +2 more
core   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Medication Treatment of Adolescent Opioid Use Disorder in Primary Care [PDF]

Pediatrics In Review, 2018
1. Brittany L. Carney, MS* 2. Scott E. Hadland, MD, MPH, MS*,† 3. Sarah M. Bagley, MD, MSc*,† 1. *Department of General Internal Medicine/Pediatrics, Boston Medical Center, Boston, MA 2. †Department of Pediatrics, Boston University School of Medicine, Boston, MA 1.
Sarah M. Bagley, Sarah M. Bagley, Brittany L. Carney, Scott E. Hadland, Scott E. Hadland   +4 more
openaire   +3 more sources

Development and use of a checklist for the implementation of medication for opioid use disorder in jails

Implementation Research and Practice, 2022
Background: In light of short lengths of stay and proximity to communities of release, jails are well-positioned to intervene in opioid use disorder (OUD). However, a number of barriers have resulted in a slow and limited implementation. Methods: This paper describes the development and testing of a Medication for Opioid Use Disorder (MOUD ...
Ariel Ludwig, Laura B. Monico, Thomas Blue, Michael S. Gordon, Robert P. Schwartz, Shannon Gwin Mitchell   +5 more
openaire   +3 more sources