Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Medication reconciliation in a hospital environment: Avoided discrepancies and cost savings - A single arm intervention study: Benefits of medication reconciliation in a hospital [PDF]
Brazilian Journal of Pharmaceutical SciencesMedication reconciliation has proven to be essential for patient safety. However, studies on its economic viability are still scarce. Therefore, the aim of this study was to understand the avoided cost of medication discrepancies identified through the ...
Lays Cássia Santos Duarte +5 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Prevalencia y caracterización de errores de medicación y conciliación en un hospital privado de segundo nivel en México | [Prevalence and characterization of medication and reconciliation errors in a second-level private hospital in Mexico] [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Although progress has been made in recent decades in the knowledge and implementation of strategies and safe practices to prevent them, medication errors remain one of the main causes of avoidable harm in healthcare.
María I. Espinosa Sánchez +5 more
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The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
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Medication Reconciliation as a Medication Safety Initiative [PDF]
, 2017 Medication errors and their adverse outcomes are the most common cause of patient injuries in hospitals. Medication reconciliation is the safety strategy usually called for, to prevent medication errors that occur at care transitions.
Mekonnen, Alemayehu B
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Effect of therapeutic interchange on medication reconciliation during hospitalization and upon discharge in a geriatric population. [PDF]
PLoS ONE, 2017 Therapeutic interchange of a same class medication for an outpatient medication is a widespread practice during hospitalization in response to limited hospital formularies. However, therapeutic interchange may increase risk of medication errors.
Jessica S Wang +2 more
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
A journey of challenges with medication reconciliation [PDF]
, 2016 Session presented on Saturday, November 7, 2015 and Sunday, November 8, 2015: Background: Unintentional medication errors are a significant problem in healthcare in terms of morbidity, mortality and cost.
Vinod, Julie
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MEDICATION RECONCILIATION: A QUALITY IMPROVEMENT PROJECT
, 2020 Medication reconciliation is a vital component of safe patient care and improving the safe use of medications in hospitals has been a Joint Commission National Patient Safety Goal since 2009 (The Joint Commission, 2020; Shah, Ishmael, & Wright, 2015 ...
Sharon L. Konrad
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