Results 51 to 60 of about 415,022 (252)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effects and Mechanisms of Jinniu Capsule on Methamphetamine-Induced Conditioned Place Preference in Rats

Open Chemistry, 2018
The aim of this study was to determine the effects of Jinniu Capsule on methamphetamine (METH)-induced conditioned place preference (CPP) in rats and identify the underlying mechanisms.
Shi Yu, Wang Feng, Hu A-Zhen, Wang Qing-Wen, Wu Jue-Lian, Li Ming-Hua, Cui Guang-Hui, Liu Li, Huang Si-Bin, Zhang Yu, Liu Han-Qing, Chen Yun   +11 more
doaj   +1 more source

Lactation safety of cardiovascular medications

American Heart Journal Plus: Cardiology Research and Practice
Breastfeeding is the gold standard for infant feeding with well-established maternal, neonatal, and pediatric benefits. Patients with preexisting cardiovascular disease have lower breastfeeding rates than the general population. While little evidence exists regarding specific barriers to lactation in patients with preexisting cardiovascular disease ...
Cristina Nunez-Pellot, Allison Akers, Sarah Običan, Mary Ashley Cain, Daniela R. Crousillat   +4 more
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Cardiac echocardiographic analysis with multi-scale effective fusion module: a novel stroke prediction approach

BMC Medical Imaging
Background Stroke remains a leading cause of death and disability, and early risk stratification is critical for prevention. Existing models based only on clinical factors may miss subtle cardiac structural and hemodynamic information visible on ...
Jiachun Xie, Dianhuan Tan, Tingting Zheng, Yun Chen, Liya Wei   +4 more
doaj   +1 more source

A Multimodal Diagnostic Model for Breast Cancer Invasiveness Based on Ultrasound Imaging and Serum Biomarkers

Medicina
Background and Objectives: Breast cancer invasiveness significantly impacts treatment strategies and prognosis. Combining ultrasound imaging modalities with serum biomarkers may improve diagnostic accuracy.
Dianhuan Tan, Yue Zhai, Zhengming Hu, Desheng Sun, Tingting Zheng   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

“But Will It Last?”: Examining How Pharmacy Staff Perceptions Influence Beliefs About the Sustainability of a Pharmacy-Based Intervention Targeting Older Adult Over-the-Counter (OTC) Medication Misuse

Pharmacy
Sustaining a well-designed healthcare intervention justifies the resources allocated during its conceptualization and implementation and maximizes its clinical benefits, but staff influences on sustainment have been studied insufficiently.
Aaron M. Gilson, Katherine G. Moore, Stephanie M. Resendiz, Emily L. Hoffins, Shiying Mai, Jamie A. Stone, Michelle A. Chui   +6 more
doaj   +1 more source

Comparison of pharmacy students randomized to receive drug information reference education via recording or interactive Moodle lesson

International Journal of Educational Technology in Higher Education, 2019
This study assessed the efficacy of an interactive Moodle lesson teaching the subject of references commonly used to answer drug information (DI) questions on pharmacy student performance and retention.
Christopher S. Wisniewski, Melissa B. Hortman   +1 more
doaj   +1 more source