Results 81 to 90 of about 426,276 (300)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Medication therapy management and adherence among US renal transplant recipients

, 2016
Marie A Chisholm-Burns,1 Christina A Spivey,1 Elizabeth A Tolley,2 Erin K Kaplan2 1Department of Clinical Pharmacy, University of Tennessee College of Pharmacy, 2Department of Preventive Medicine, University of Tennessee College of Medicine, Memphis, TN,
Chisholm-Burns MA, Spivey CA, Tolley EA, Kaplan EK   +3 more
core  

People with insomnia: experiences with sedative hypnotics and risk perception

, 2016
Background - Sedative hypnotics form an important part of managing insomnia and are recommended for short-term use. It is standard practice for clinicians to inform the patient to use medications only ‘when required’, but the use of these medications is ...
Saini, Bandana, Delwyn J. Bartlett, Bartlett, Delwyn, Janet M. Y. Cheung, Ellis, Jason, Bandana Saini, Jason G. Ellis, Cheung, Janet, Armour, Carol, Carol L. Armour   +9 more
core   +1 more source

New medical therapies in glaucoma management

Journal of Osteopathic Medicine, 1997
Abstract New and potent medications such as alpharadrenergic agonists, topically active carbonic anhydrase inhibitors, and prostaglandin analogs, are now available for use in the treatment of glaucoma. These ophthalmic medications have the potential to cause serious drug interactions and systemic side effects.
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The impact of pharmacist-led medication therapy management on medication adherence in patients with type 2 diabetes mellitus: a randomized controlled study

, 2017
Background: Poor adherence to antidiabetic medications leads to a higher rate of hospital admissions and adverse health outcomes in type 2 diabetes mellitus patients.
Erku, Daniel A, Henok G. Tegegn, Sewunet A. Belachew, Hailemeskel, Bisrat, Bisrat Hailemeskel, Ayele, Asnakew A., Daniel A. Erku, Tegegn, Henok G, Erku, Daniel A., Asnakew A. Ayele, Mekuria, Abebe B, Tegegn, Henok G., Belachew, Sewunet A., Ayele, Asnakew A, Belachew, Sewunet A, Mekuria, Abebe B., Abebe B. Mekuria   +16 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Respiratory medication use in Australia 2003–2013: treatment of asthma and COPD [PDF]

, 2015
This report describes patterns of dispensing of respiratory medications in Australia through detailed analyses of Pharmaceutical Benefits Scheme data, as well as other sources, to draw inferences about respiratory medication use among patients with ...
Leanne Poulos, Patricia Correll, H. K. Reddel, Rosario Ampon, Guy Marks   +4 more
core  

Identification of Barriers for Active Disease Management and of Medication-Related Problems through Therapeutic Patient Education in Older Home-Care Patients [PDF]

Combining therapeutic patient education (TPE) with a medication review service could foster the adoption of appropriate lifestyles by patients and support care-providers in identifying strategies to improve the quality of prescribed care.
Grigolo, Sabrina, Di Masi, Diego, Cena, Clara, Diego Di Masi, Bruschi, Barbara, Lucrezia Greta Armando, Clara Cena, Armando, Lucrezia Greta, Barbara Bruschi, Carla Bena, Sabrina Grigolo   +10 more
core   +1 more source

An Overview of Pharmacological Approaches for Management and Repair of Spinal Cord Injuries [PDF]

Iranian Journal of Psychiatry, 2010
"nSpinal cord injury (SCI) leads to loss of nervous tissue and consequently to catastrophic neurological deficits. Up to now there is no definite treatment available that restores the loss of function to a degree that an independent life can be ...
Azam Mardani, Alireza Khoshnevisan, Shahab kamali   +2 more
doaj   +2 more sources