Results 41 to 50 of about 1,206,345 (314)

Effectiveness, tolerability and practical application of the newer generation anti-obesity medications [PDF]

, 2016
Objective: Comparison of the efficacy and tolerability of five newer anti-obesity medications to guide clinical decision making, examining bupropion–naltrexone combination, liraglutide, lorcaserin, orlistat, and phentermine–topiramate combination ...
Thomas L Schwartz, Jeffrey S MacDaniels
core   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice

Translational Psychiatry
G protein-coupled receptor 55 (GPR55) has been thought to be a putative cannabinoid receptor. However, little is known about its functional role in cannabinoid action and substance use disorders.
Yi He, Hui Shen, Guo-Hua Bi, Hai-Ying Zhang, Omar Soler-Cedeño, Hannah Alton, Yihong Yang, Zheng-Xiong Xi   +7 more
doaj   +1 more source

The Structural Basis of the Activity Cliff in Modafinil-Based Dopamine Transporter Inhibitors

Biomolecules
Modafinil analogs with either a sulfoxide or sulfide moiety have improved binding affinities at the human dopamine transporter (hDAT) compared to modafinil, with lead sulfoxide-substituted analogs showing characteristics of atypical inhibition (e.g ...
Kuo-Hao Lee, Gisela Andrea Camacho-Hernandez, Amy Hauck Newman, Lei Shi   +3 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

EUROPEAN TERATOLOGY INFORMATION SERVICE: EXPERIENCE, PROBLEMS AND PERSPECTIVES

Педиатрическая фармакология, 2007
Congenital malformations are still the important medical and social issue. They take the second place among the reasons for the infant mortality and cause up to 18,3% of disablement cases among the children. Exogenous factors, effecting the growing fetus,
A.V. Ostrovskaya, K. Schefer, L. von Stackelberg   +2 more
doaj   +2 more sources

Neutral CB1 Receptor Antagonists as Pharmacotherapies for Substance Use Disorders: Rationale, Evidence, and Challenge

Cells, 2022
Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication development for treating substance use disorders (SUDs). Early studies indicated that rimonabant, a selective CB1R antagonist with an inverse agonist profile, was highly ...
Omar Soler-Cedeno, Zheng-Xiong Xi
doaj   +1 more source

Anxiety disorders, PTSD and OCD: systematic review of approved psychiatric medications (2008-2024) and pipeline phase III medications. [PDF]

OBJECTIVE: This systematic review examines psychiatric medications approved by the FDA for anxiety disorders, post-traumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD) from 2008 to 2024 and describes the mechanism of action ...
Padder, Samar, Drew Hirsch, Danovitch, Itai, Mercado, Krista, Sabrina Renteria, Pechnick, Robert, Jayant Totlani, Totlani, Jayant, Hirsch, Drew, Itai Danovitch, Renteria, Sabrina, Naqvi, Aasim, Meyer, Ashley, Lorena Contreras, Tadros, Emile, Samar Padder, Ashley Meyer, Kaidbay, Daniel, Kaidbay, Daniel N, Contreras, Lorena, Waguih William IsHak, Daniel N Kaidbay, Miles, Samuel, IsHak, Waguih, Aasim Naqvi, Shirley Keerthana, Krista Mercado, Samuel Miles, Robert N Pechnick, Keerthana, Shirley, Pechnick, Robert N, IsHak, Waguih William, Emile Tadros   +32 more
core   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

EFFICIENCY OF THE NEW MEDICATION OF FS-1 IN THE TREATMENT OF EXPERIMENTAL TUBERCULOSIS

Туберкулез и болезни лёгких, 2015
In vitro studies have proved the anti-tuberculosis eŠect of FS-1 medication both against susceptible strain of M. tuberculosis H37Rv, and the strain of M. tuberculosis MS-115 with multiple drug resistance.Conducted in vivo studies on guinea pigs infected
M. E. Kulmanov, B. F. Kerimzhanova, L. N. Chernousova, I. V. Bocharova, L. N. Lepekha, A. I. Il'in   +5 more
doaj