Results 31 to 40 of about 1,206,345 (314)

Case Report: The Complexities of Managing Medications and the Importance of Deprescribing Anticholinergics in Older Adults

Frontiers in Pharmacology, 2021
Potentially inappropriate anticholinergic medications (including over-the-counter products), polypharmacy, and the existence of communication barriers among members of the interprofessional team frequently contribute to clinical complexity in older ...
Taylor Elliott, Lynne Eckmann, Daniela C. Moga, Daniela C. Moga, Daniela C. Moga   +4 more
doaj   +1 more source

Out‐of‐hospital ketamine: review of a growing trend in patient care

Journal of the American College of Emergency Physicians Open, 2020
Ketamine is a unique medication with a long history of use in the emergency department. Out‐of‐hospital indications for ketamine have been explored and are currently expanding in some systems.
Bryan B. Kitch
doaj   +1 more source

An exploratory study on medications in Qatar homes [PDF]

, 2011
N Kheir1, MS El Hajj1, K Wilbur1, RML Kaissi1, A Yousif21College of Pharmacy, 2College of Arts and Sciences, Qatar University, Doha, QatarBackground: Drug therapy is the most often used intervention for treatment and prevention of disease.
Kheir N, Kaissi, R.M.L., Kheir, N., Wilbur, K., Kaissi RML, El Hajj MS, El Hajj, M.S., Yousif A, Wilbur K, Yousif, A.   +9 more
core   +1 more source

Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

Biomolecules, 2021
The dopamine D2/D3 receptor (D2R/D3R) agonists are used as therapeutics for Parkinson’s disease (PD) and other motor disorders. Selective targeting of D3R over D2R is attractive because of D3R’s restricted tissue distribution with potentially fewer side ...
Pramisha Adhikari, Bing Xie, Ana Semeano, Alessandro Bonifazi, Francisco O. Battiti, Amy H. Newman, Hideaki Yano, Lei Shi   +7 more
doaj   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

RDS-04-010: a novel atypical DAT inhibitor that inhibits cocaine taking and seeking and itself has low abuse potential in experimental animals

Translational Psychiatry
Cocaine use disorder (CUD) is a severe public health problem, and currently, there is no FDA-approved medication for its treatment. Atypical dopamine (DA) transporter (DAT) inhibitors display low addictive liability by themselves and may have therapeutic
Omar Soler-Cedeno, Ewa Galaj, Benjamin Klein, Jianjing Cao, Guo-Hua Bi, Amy Hauck Newman, Zheng-Xiong Xi   +6 more
doaj   +1 more source

NEW DIRECTIONS IN ATHEROSCLEROSIS PHARMACOTHERAPY

Кардиоваскулярная терапия и профилактика, 2017
In the review, recent data presented, on possible targets for medications of specific pathogenetic action in atherosclerosis. The results described, of application of some drugs in complex treatment of atherosclerotic vessels lesions.
S. V. Dutova, Yu. V. Saranchina, O. Yu. Kilina, N. G. Polshcha, T. S. Kulakova, N. V. Khanarin   +5 more
doaj   +1 more source

A comprehensive evaluation of the potential binding poses of fentanyl and its analogs at the µ-opioid receptor

Computational and Structural Biotechnology Journal, 2022
Fentanyl and its analogs are selective agonists of the µ-opioid receptor (MOR). Among novel synthetic opioids (NSOs), they dominate the recreational drug market and are the main culprits for the opioid crisis, which has been exacerbated by the COVID-19 ...
Bing Xie, Alexander Goldberg, Lei Shi
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

CONTEMPORARY STRATEGY OF PULMONARY HYPERTENSION MANAGEMENT IN PEDIATRICS

Кардиоваскулярная терапия и профилактика, 2018
Pulmonary hypertension (PH) in pediatrics is a polygenic multifactorial condition with extremely adverse prognosis. Selection of optimal management is a severe task. In absence of treatment the mean life duration in children is not higher one year.
I. M. Miklashevich, М. A. Shkolnikova, S. V. Gorbachevsky, A. A. Shmalts, О. S. Groznova, D. I. Sadykova, L. V. Yakovleva, D. N. Degtyarev, A. A. Burov, D. Yu. Ovsyannikov, A. V. Volkov   +10 more
doaj   +1 more source