Results 131 to 140 of about 14,605 (264)

Placebo Effect in Levodopa‐Induced Dyskinesia: A Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Levodopa‐induced dyskinesia (LID) is a complication of Parkinson's disease (PD) treatment. While the placebo effect is a known component in PD clinical trials, its specific magnitude in the context of LID is not well characterized.
Luiz Vinicius Silva Correa, Alexandre Martins do Nascimento, Bruno Lopes Santos‐Lobato, Henry Mauricio Chaparro‐Solano, Ignacio Fernandez Mata, Vitor Tumas   +5 more
wiley   +1 more source

Redefining “Comorbidity” in Dermatology: Beyond Terminology, Lessons From Other Specialties

JEADV Clinical Practice, EarlyView.
Patricia Garbayo‐Salmons, Mireia Moreno   +1 more
wiley   +1 more source

The Global Parkinson's Disease Genetics (GP2) Genome Browser

Movement Disorders, EarlyView.
Abstract Background Large‐scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease‐causing variants, we developed an open‐access, summary‐level genomic data browser.
Zih‐Hua Fang, Riley H. Grant, Dan Vitale, Carlos F. Hernandez, Samantha Hong, Hampton L. Leonard, Mary B. Makarious, Lara M. Lange, Matthew Solomonson, Peter Heutink, Allison A. Dilliott, Kamalini Ghosh Galvelis, Mike A. Nalls, Andrew B. Singleton, Cornelis Blauwendraat, the Global Parkinson's Genetics Program (GP2)   +15 more
wiley   +1 more source

Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study

Movement Disorders, EarlyView.
Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Monica M. Kurtis, Alexander Storch, José‐Francisco Rocha, Raquel Costa, Diogo Magalhães, Guillermo Castilla‐Fernández, Helena C. Brigas, Joerg Holenz, Per Odin, on behalf of the OCEAN study group   +13 more
wiley   +1 more source

Chronic Pruritic Papular Eruption in an Elderly Man

JEADV Clinical Practice, EarlyView.
Filipe Monteiro, Inês Tribolet‐Abreu, Gustavo Almeida‐Silva, Inês Amaral, Ivânia Soares, Sónia Fernandes, Joana Antunes   +6 more
wiley   +1 more source

Safety and Efficacy of Glucagon‐Like Peptide‐1 Receptor Agonists Use in Elderly People With Obesity—A Meta‐Analysis

Obesity, EarlyView.
ABSTRACT Objective This meta‐analysis evaluates the safety and efficacy of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) for the treatment of older adults with obesity compared to younger individuals. Methods A systematic review was conducted following PRISMA guidelines (PROSPERO CRD420251074381).
Inês Rego de Figueiredo, Filipa Sofia Simas, Angela Ghiletchi, João Oliveira Torres, José Silva‐Nunes   +4 more
wiley   +1 more source

Error Traps in Pediatric Neuromuscular Block

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological ...
Gabriel Soares de Sousa, Debra Faulk, Vinicius Caldeira Quintao, Niekoo Abbasian, Hans D. de Boer, Ricardo Vieira Carlos   +5 more
wiley   +1 more source

Perioperative Adverse Events in Primary Palatoplasty: “Risk Factors and Impact on Care Escalation in a Multicenter Cohort”

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Patients undergoing palatoplasty experience perioperative adverse events. Identifying risk factors for perioperative adverse events and escalation of care may improve outcomes. Methods Pediatric patients undergoing primary palatoplasty were included in this retrospective observational study performed at two academic children's ...
Febina Padiyath, Elizabeth M. O'Brien, Jennifer Nam, Paula Hu, Nishil Mehta, Marc Parris, Anthony Alexander, Ashley Hodges, Goretti Chiang, Vinícius Caldeira Quintão, Ricardo Vieira Carlos, Gabriel Soares de Sousa, Asif Padiyath, Susan C. Nicolson, John Fiadjoe, Oksana A. Jackson, Lisa K. Lee, Annery G. Garcia‐Marcinkiewicz   +17 more
wiley   +1 more source

Multiple Roles of Protamine Kinase SRPK1 and Phosphatase PP1γ in Sperm Development

PROTEOMICS, EarlyView.
ABSTRACT Protein phosphorylation regulates key events of male germ cell differentiation. In the testis, SRPK1 and PP1γ are involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility.
Alberto de la Iglesia, Mélina Blanco, Meritxell Jodar, Olivier Feudjio, Marjorie Leduc, Judit Castillo, Julie Cocquet, Rafael Oliva   +7 more
wiley   +1 more source

Drought stress modulates indirect defense via bottom‐up effects in tomato and wheat

Pest Management Science, EarlyView.
Different water regimes can have a significant impact on plant morphology and defense pathways in tomato and wheat, triggering multiple olfactory choices in biocontrol agents of key insect pests. These findings could be used to implement biocontrol strategies within the IPM context under a changing climate scenario.
Mariangela Milordo, Eya Ben Hmad, Maria Flavia Pitruzzello, Carmelo Cavallaro, Giuseppe Massimino Cocuzza, Lucia Zappalà, Peng Han, Antonio Biondi, Michele Ricupero   +8 more
wiley   +1 more source