Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Galectin-1 is essential for efficient liver regeneration following hepatectomy [PDF]
, 2016 Galectin-1 (Gal1) is a known immune/inflammatory regulator which actsboth extracellularly and intracellularly, modulating innate and adaptive immuneresponses. Here, we explored the role of Gal1 in liver regeneration using 70% partial hepatectomy (PHx) of
Cerliani, Juan Pablo +7 more
core +1 more source
Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease [PDF]
, 2016 Dry eye is an allegedly autoimmune disorder for which the initiatingmechanisms and the targeted antigens in the ocular surface are not known,yet there is extensive evidence that a localized T helper type 1 (Th1)/Th17effector T cell response is ...
Galletti, Jeremías Gastón +5 more
core +1 more source
Dynamic mitochondrial–nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation [PDF]
, 2013 Glucocorticoids play an important role in adipogenesis via the glucocorticoid receptor (GR) that forms a heterocomplex with Hsp90•Hsp70 and one high molecular weight immunophilin FKBP51 or FKBP52.
Charó, Nancy Lorena +6 more
core +2 more sources
Molecular and functional characterization of a Trypanosoma cruzi nuclear adenylate kinase isoform [PDF]
, 2013 Trypanosoma cruzi, the etiological agent of Chagas’ disease, is an early divergent eukaryote in which control of gene expression relies mainly in post-transcriptional mechanisms.
Bouvier, Leon Alberto +4 more
core +4 more sources
Brazilian Journal of Radiation Sciences, 2015 Neste estudo foram avaliados os riscos de exposição ocupacional interna associados à incorporação de 131I, via inalação, em Serviços de Medicina Nuclear, utilizando técnicas de análise de aerossóis.
Luana Gomes Carneiro +5 more
doaj +1 more source
Environmental Pollutant Hexachlorobenzene Induces Hypertension In a Rat Model [PDF]
, 2018 Hexachlorobenzene (HCB) is a dioxin-like environmental pollutant, widely distributed in the environment. New research links exposure to high levels of persistent organic environmental toxicants to cardiovascular disease, however little is known about the
Alvarez, Laura +8 more
core +1 more source
Reactive oxygen species and extracellular signal-regulated kinase 1/2 mediate hexachlorobenzene-induced cell death in FRTL-5 rat throyd cells [PDF]
, 2013 Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. We have previously shown that chronic HCB exposure triggers apoptosis in rat thyroid follicular cells.
Alvarez, Laura +4 more
core +2 more sources
Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness [PDF]
, 2014 Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen activated protein kinases (MAPK)
Bal, Elisa Dora +7 more
core +1 more source