Hybrid (2D/3D) Dosimetry of Radiolabeled Gold Nanoparticles for Sentinel Lymph Node Detection in Patients with Breast Cancer. [PDF]
Previously, we reported the preparation and preclinical studies of 99mTc‐labeled gold nanoparticles‐mannose (99mTc‐AuNP‐mannose) with potential for sentinel lymph node (SLN) detection by using nuclear medicine procedures. This study aimed to evaluate the biokinetics and hybrid (2D/3D) dosimetry of 99mTc‐AuNP‐mannose in five patients with breast cancer ...
Ramírez-Nava G +7 more
europepmc +2 more sources
99mTc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans. [PDF]
Overexpression of the chemokine‐4 receptor (CXCR4) in brain tumors is associated with high cancer cell invasiveness. Recently, we reported the preclinical evaluation of 99mTc‐CXCR4‐L (cyclo‐D‐Tyr‐D‐[NMe]Orn[EDDA‐99mTc‐6‐hydrazinylnicotinyl]‐Arg‐NaI‐Gly) as a SPECT radioligand capable of specifically detecting the CXCR4 protein.
Vallejo-Armenta P +10 more
europepmc +2 more sources
177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: Biokinetics, Dosimetry, and Evaluation in Patients with Advanced Prostate Cancer. [PDF]
SPECT/CT images in patients have demonstrated the ability of [99mTc]Tc‐EDDA/HYNIC‐Lys(Nal)‐Urea‐Glu ([99mTc]Tc‐iPSMA) to detect tumors and metastases of prostate cancer. Considering that theranostics combines the potential of therapeutic and diagnostic radionuclides in the same molecular probe, the aim of this research was to estimate the biokinetics ...
Santos-Cuevas C +9 more
europepmc +2 more sources
Mie theory explains the interaction of light with a gold nanoparticle (AuNP) through the absorption (Cabs), scattering (Csca), and extinction (Cext) cross sections. These parameters have been calculated in the case of AuNPs dispersed in homogeneous media, but not for specific tissues.
A. Carrillo-Cazares +5 more
wiley +1 more source
Cancer is one of the diseases with most deaths worldwide, around 8.2 million annually. For this reason, several treatments and diagnostic tools have been investigated and developed over the past decades. Among them, a dual‐image system has been developed to achieve and enhance the detection of cancer, which has not been done with systems currently ...
Alejandra Ancira-Cortez +7 more
wiley +1 more source
Recent studies have demonstrated that drug antimicrobial activity is enhanced when metallic nanoparticles are used as an inorganic support, obtaining synergic effects against microorganisms. The cationic antimicrobial peptide ubiquicidin 29–41 (UBI) has demonstrated high affinity and sensitivity towards fungal and bacterial infections.
Enrique Morales-Avila +7 more
wiley +1 more source
177Lu‐labeled nanoparticles conjugated to biomolecules have been proposed as a new class of theranostic radiopharmaceuticals. The aim of this research was to synthesize 177Lu‐dendrimer(PAMAM‐G4)‐folate‐bombesin with gold nanoparticles (AuNPs) in the dendritic cavity and to evaluate the radiopharmaceutical potential for targeted radiotherapy and the ...
Héctor Mendoza-Nava +9 more
wiley +1 more source
[SARS-Cov-2 vaccination and metabolic radionuclide therapy: document of the SEMNIM Endocrinology Working Group]. [PDF]
Negre Busó M +3 more
europepmc +2 more sources
Regulation of nuclear medicine services: Perception of the problems and challenges in Colombia for the approach to cancer [PDF]
Murcia EM +5 more
europepmc +1 more source
Development and Characterization of 99mTc-scFvD2B as a Potential Radiopharmaceutical for SPECT Imaging of Prostate Cancer. [PDF]
Bolzati C +10 more
europepmc +1 more source

