Results 1 to 10 of about 126,087 (296)

Safety Study of an Original Mesenchymal Stromal Cell Secretome-Based Medicinal Product for Spermatogenesis Restoration

Безопасность и риск фармакотерапии
SCIENTIFIC RELEVANCE. Currently, there are no effective and safe medicinal products for idiopathic male infertility. Previous studies in two animal models of infertility (short-term cryptorchidism in rats and doxorubicin-induced testicular injury in mice)
A. O. Monakova, G. D. Sagaradze, V. Yu. Balabanyan, N. A. Basalova, A. A. Matichina, A. A. Matichin, K. L. Kryshen, V. S. Popov, Zh. A. Akopyan, A. Yu. Efimenko   +9 more
doaj   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mango, the king of fruits, with fascinating pharmacological activities and medicinal uses

Open Veterinary Journal
Mango (Mangifera sp.; family: Anacardiaceae) is one of the most widely consumed fruits globally due to its rich and aromatic flavor, which is balanced with a pleasant balance of sweetness and acidity.
Hala T. Mahmoud, Hassan A. Nabil, Ali A. Shahein, Wageh Sobhy Darwish, Zeinab A. Mohamed   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Effect of Medicinal Plants on Probiotic Bacteria: A Review [PDF]

International Journal of Nutrition Sciences
Probiotics are one of the functional and useful microorganisms that protect the host against many diseases and are used as live food supplements in food industry.
Mohammad Hossein Marhamatizadeh, Maryam Rafat   +1 more
doaj   +1 more source

Medicinal Animals and Plants as Alternative and Complementary Medicine in Southern Regions of Khyber Pakhtunkhwa, Pakistan. [PDF]

Front Pharmacol, 2021
Mussarat S, Ali R, Ali S, Mothana RA, Ullah R, Adnan M.   +5 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Medicinal plants: A source of phytobiotics for the feed additives

Journal of Agriculture and Food Research
Medicinal plants are a rich source of secondary metabolites, which can be used in veterinary medicine as growth stimulants and as next-generation antibacterials.
Svetlana Ivanova, Stanislav Sukhikh, Alexander Popov, Olga Shishko, Ilia Nikonov, Elena Kapitonova, Olesia Krol, Viktoria Larina, Svetlana Noskova, Olga Babich   +9 more
doaj   +1 more source

Traditional-medical knowledge and perception of pangolins (manis sps) among the awori people, Southwestern Nigeria

Journal of Ethnobiology and Ethnomedicine, 2011
Background Animals have been used as medicinal resources throughout human history. Majority of wildlife used in traditional medicines is taken from the wild; hence demand by traditional medicine is a cause of over-exploitation of wild animals ...
Adekanola Temilolu A, Soewu Durojaye A
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source