Results 231 to 240 of about 282,673 (304)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The Pre-Linnaean Herbarium of Paolo Boccone (1633-1704) in Wrocław, Poland: Its History, Description, its Purpose, and its Usefulness for Historians of Science. [PDF]

J Hist Biol
Grenda-Kurmanow M, Drobnik J, Stebel A, Alziar G.   +3 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Investigations of the voltage-gated Ca⁺⁺ channels and phosphodiesterase enzyme inhibitory-like potential explain the medicinal use of <i>Otostegia fruticosa</i> in diarrhea and hypermotile gut. [PDF]

Front Pharmacol
Rehman NU, Ansari MN, Alalaiwah NA, Alotibi EO, Karim A, Bahta T, Abujheisha KY, Noman M.   +7 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Phytotherapeutic Intervention in Monosodium Glutamate-Induced Uterine Dysfunction: Efficacy of <i>Lepidium sativum, Prunus armeniaca, Stachys palustris,</i> and <i>Solenostemma argel</i>. [PDF]

Pharmaceuticals (Basel)
ElNebrisi E, El Rouby NM, Noori FM, Jalali NA, Fouad Saber RM, Abdalla Mohamed ZS, Shehab NG.   +6 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Harnessing the Medicinal Potential of Enset (<i>Ensete ventricosum</i>) in Ethiopian Traditional Medicine: A Synthesis of Current Knowledge. [PDF]

Food Sci Nutr
Muanenda M, Fereja WM, Dauda WP.
europepmc   +1 more source