Results 71 to 80 of about 1,562,094 (290)
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Economic Impacts of Vertebrate Pests in Australia
Invasive animal pests have a wide variety of impacts on the economy, the environment and society. There is considerable information on these impacts for individual cases and regions, and McLeod (2004) attempted to value them nationwide for a whole range ...
Sinden, Jack A +5 more
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Ethnobotanical and ethnoveterinary study of medicinal plants used in the municipality of Bom Princípio do Piauí, Piauí Brazil. [PDF]
Knowledge of medicinal plants has accumulated over centuries and often represents the only therapeutic resource of small municipalities in the interior of Brazil.
MAYO, S. J. +8 more
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Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Advances in the application of medicinal plants in culture of tilapia
Medicinal plants are rich in nutrients and immunoactive substances. It is an important task for green and sustainable development of aquaculture to screen and develop medicinal plant products for aquatic animals. In the paper, advances in the application
Jia-rui XU +6 more
doaj
Medicinal use of animals by hunters in North eastern Brazil [PDF]
485-493Animals (and their by-products) are used worldwide in the preparation of many traditional medicines. Despite this, research on medicinal use of animals is still neglected in comparison to studies on medicinal plants.
Aguiar, José Otávio +2 more
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