Results 91 to 100 of about 2,645,063 (296)
Editorial: Excellence in Medicinal Chemistry from Australia
, 2017 The medicinal chemistry research published in the Journal of Medicinal Chemistry by corresponding authors based in Australia predominantly originated from Australian universities, with academic authors accounting for 49 of the 52 manuscripts published in
Sally-Ann Poulsen, Poulsen, Sally-Ann
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A convenient solid phase synthesis of S-palmitoyl transmembrane peptides [PDF]
, 2005 S-Palmitoylated peptides are important tools as models for integral membrane proteins to study peptide–lipid interactions. Herein, we report a convenient solid phase synthesis of S-palmitoyl transmembrane peptides.
Rijkers, D.T.S. +9 more
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Open access and medicinal chemistry
Chemistry Central Journal, 2007 Chemistry Central is a new open access website for chemists publishing peer-reviewed research in chemistry from a range of open access journals.
Swain Chris
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Semi-synthesis of nisin-based peptide antibiotics [PDF]
, 2013 There is a growing need for novel antibiotics since there are more and more cases of infections caused by resistant bacteria. Possible novel antibiotics are antimicrobial peptides, especially the lantibiotic nisin.
Medicinal Chemistry and Chemical Biology +2 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Synthesis of Triazole Bridged Vancomycin Mimics [PDF]
, 2012 Cyclic peptides are an important class of compounds with broad biological activities. Both natural as well as synthetic cyclic peptides have been recognized as a great resource and inspiration for drug discovery.
Medicinal Chemistry and Chemical Biology +2 more
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source