Results 81 to 90 of about 2,645,063 (296)

Fluorine in medicinal chemistry

Chem. Soc. Rev., 2008
It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine ...
Purser, S, Moore, P, Swallow, S, Gouverneur, V   +3 more
openaire   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade

, 2021
3-Phenylcoumarins are a family of heterocyclic molecules that are widely used in both organic and medicinal chemistry. In this overview, research on this scaffold, since 2010, is included and discussed, focusing on aspects related to its natural origin ...
Eugenio Uriarte, Maria J. Matos, Uriarte, Eugenio, Santana, Lourdes, Lourdes Santana, Matos, Maria J.   +5 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Protein mimics by molecular scaffolding of peptides [PDF]

, 2016
The research in this thesis aimed at the development of a new route for the synthesis of discontinuous epitope mimics. Mimicry of discontinuous epitopes is often achieved through mounted peptides corresponding to the epitope sequence on a molecular ...
Medicinal Chemistry and Chemical Biology, Werkhoven, P.R., Sub Medicinal Chemistry & Chemical biol.   +2 more
core  

Medicinal Chemistry: A Teacher's and Worker's Perspective

CHIMIA, 1992
This personal commentary aims at offering a description of the origin, purpose, and methods of medicinal chemistry, and a delineation of its fields of activity in connection with related sciences.
Bernard Testa
doaj   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

ACS Medicinal Chemistry Letters. member of the Editorial Board

, 2014
ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization ...
COSTI, Maria Paola
core  

Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state2H NMR study [PDF]

, 2005
To gain insight into the parameters that determine the arrangement of proteins in membranes, 2H NMR experiments were performed to analyze tilt and rotation angles of membrane-spanning α-helical model peptides upon incorporation in ...
Rijkers, D.T.S., Medicinal Chemistry, Biochemie van Membranen, Dep Farmaceutische wetenschappen, SYNTHESE, Özdirekcan, S., Liskamp, R.M.J., Dep Scheikunde, Killian, J.A., Medicinal Chemistry van immunologische en neurologische ziekteprocessen   +9 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source