Results 131 to 140 of about 155,115 (251)

The many facets of sustainability in medicinal chemistry: our personal experience. [PDF]

RSC Med Chem
Martinengo B, Diamanti E, Uliassi E, Bolognesi ML.   +3 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry. [PDF]

ChemistryOpen
Ten A, Koizhaiganova R, Bissenbay D, Tursynova B, Zhaxibayeva Z, Yu V.   +5 more
europepmc   +1 more source

Biphenyl as a Privileged Structure in Medicinal Chemistry: Advances in Anti-Infective Drug Discovery. [PDF]

Molecules
Gandi MO, França RRF, Castelo-Branco FS, Boechat N.   +3 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

The Evolution of Machine Learning in Medicinal Chemistry: A Comprehensive Bibliometric Analysis. [PDF]

Curr Neuropharmacol
Wang Y, Guan T, Xu D, Liu M, Zhang Z.
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Encapsulation of carbon dots in medicinal chemistry: a comprehensive review of recent advances and applications. [PDF]

RSC Adv
Mohammed SJ, Ali KM, Mustafa FS, Najmuldeen HH, Alghofaili F, Sidiq MK, Kayani KF.   +6 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Recent Advancements in the Diversification and Applications of Boron-Containing Compounds in Medicinal Chemistry. [PDF]

Pharmaceuticals (Basel)
Frooman MB, Deb MK, Peters J, Leggett S, Sanghai N, Rizvi NZ, Atukorallaya D, Tranmer GK.   +7 more
europepmc   +1 more source