Results 141 to 150 of about 2,645,063 (296)

The Future of Medicinal Chemistry [PDF]

Angewandte Chemie International Edition, 2012
Torsten, Hoffmann, Rainer, Metternich
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Recent advances in synthesis and medicinal chemistry of pyrrolodiazepines. [PDF]

Front Chem
Zhou M, Wang S.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Role of Trifluoromethyl and Trifluoromethoxy Groups in Medicinal Chemistry: Implications for Drug Design

One of the key strategies in drug design involves modifying molecular scaffolds with specific chemical groups, or side chains, to enhance biological and physicochemical properties.
Maria J. Matos, Manuel Novás
core   +1 more source

Tearing Down Scientific Boundaries: Frontiers in Medicinal Chemistry 2026. [PDF]

ChemMedChem
Heitel P, Barbie P, Gambardella A, Pinto M, Pape F, Tarasewicz A, Hessler G, Wünsch B, Schiedel M, Lamers C.   +9 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pyridinium and related azinium salts in organic synthesis and medicinal chemistry. [PDF]

RSC Adv
Mohammadi Mehr E, Alavi SM, Akbari M, Yazzaf R, Davaran S, Sepehri S, Mahdavi M.   +6 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

[From gene to drug: recent developments in medicinal chemistry]

, 2008
The development ofa new drug often takes more than ten years. Until recently, researchers were obliged to carry out experimental research on the efficacy of variants of those molecules of which the effect was known. It took a long time before a structure-
Leurs, R, de Esch, I.J.P.; id_orcid, de Esch, I J P; id_orcid, de Esch, I.J.P., Leurs, R.   +4 more
core