Results 211 to 220 of about 155,115 (251)
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Venomics in Medicinal Chemistry
Future Medicinal Chemistry, 2014Venom peptides mainly target ion channels, but also GPCRs, transporters and enzymes with high affinity and exquisite selectivity. The intermediate size of these peptidic toxins and their proteinaceous nature make them particularly suited formedicinal chemistry.
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Macromolecular Chemistry and Medicine
Angewandte Chemie International Edition in English, 1970AbstractMacromolecular substances are used in medicine both as materials and as reagents. In the former category polymers serve as replacements for soft tissue, as cardiovascular and orthopedic implants, and as adhesives. When employed as reagents, macromolecules interact with living tissue and play an active part in bodily repair processes.
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Fluorine in Medicinal Chemistry
ChemBioChem, 2004AbstractFluorinated compounds are synthesized in pharmaceutical research on a routine basis and many marketed compounds contain fluorine. The present review summarizes some of the most frequently employed strategies for using fluorine substituents in medicinal chemistry. Quite often, fluorine is introduced to improve the metabolic stability by blocking
Hans-Joachim, Böhm +7 more
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Proteomics in Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry, 2006Proteomics is becoming an important research area for studying protein expression patterns induced by different external stimuli. An important aspect of proteomics is to identify and quantify proteins. Many new technologies and techniques have been developed in this field and have been applied to various aspects of drug discovery.
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Fluorine in Medicinal Chemistry
2015Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal chemistry has become commonplace, with the small electronegative fluorine atom being a key part of the medicinal chemist's repertoire of substitutions used to modulate all aspects of molecular properties including potency, physical chemistry and ...
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Automation in Medicinal Chemistry
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
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The impact of click chemistry in medicinal chemistry
Expert Opinion on Drug Discovery, 2012The copper(I)-catalyzed 1,3-dipolar cycloaddition of alkynes and azides to form 1,2,3-triazoles is the most popular reaction in click chemistry. This reaction is also near-perfect, in terms of its robustness, due to the high degree of reliability and complete specificity.
Jingli, Hou +4 more
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2003
In the past decade, nuclear magnetic resonance (NMR) spectroscopy has gained an enormous impact on drug research, due to its extraordinary capacity to measure properties and observe changes at individual atomic positions even in very complex systems. While the analysis of molecular structures still is the main goal of classical NMR investigations, it ...
Kessler, H. +5 more
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In the past decade, nuclear magnetic resonance (NMR) spectroscopy has gained an enormous impact on drug research, due to its extraordinary capacity to measure properties and observe changes at individual atomic positions even in very complex systems. While the analysis of molecular structures still is the main goal of classical NMR investigations, it ...
Kessler, H. +5 more
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Current Medicinal Chemistry, 2014
Over the last centuries, there were many important discoveries in medicine that were crucial for gaining a better understanding of several physiological processes. Molecular modelling techniques are powerful tools that have been successfully used to analyse and interface medicinal chemistry studies with electrochemical experimental results.
M O, Almeida +5 more
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Over the last centuries, there were many important discoveries in medicine that were crucial for gaining a better understanding of several physiological processes. Molecular modelling techniques are powerful tools that have been successfully used to analyse and interface medicinal chemistry studies with electrochemical experimental results.
M O, Almeida +5 more
openaire +2 more sources