Results 201 to 210 of about 3,137,400 (295)

Introducing the 2026 Early Career Board of <i>ACS Medicinal Chemistry Letters</i>. [PDF]

ACS Med Chem Lett
Axtman A, Goldstein S, Hlozek J, Monti L, Shen C, Shevick SL, Uguen M, Vukelic S, Watson E, Xiong R, Zhang X, Zhang Z, De Vita E, Fosu SC, Raouf YS.   +14 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Session Medicinal Chemistry & Chemical Biology

CHIMIA, 2017
Spichiger David
doaj   +2 more sources

Session Medicinal Chemistry & Chemical Biology

CHIMIA, 2020
David Spichiger
doaj  

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry. [PDF]

ChemMedChem
Vogel IC, Verganista MJ, Candeias NR.
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Session Medicinal Chemistry & Chemical Biology

CHIMIA, 2022
Céline Wittwer
doaj  

Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000-2025). [PDF]

Med Res Rev
Al-Karmalawy AA, Al-Dakhil A, Ashour NA, Yousef TA, Mabrouk SS, Khatib AOA, Hawas SS.   +6 more
europepmc   +1 more source

Recent Advances in Pyrazole-Based Cholinesterase Inhibitors: Medicinal Chemistry Perspectives from 2020 to 2025. [PDF]

Pharmaceuticals (Basel)
Yeysin L, Akın D, Çalışkan S, Hasanoğlu Özkan E, Hashem H, Akocak S, Bräse S, Çete S.   +7 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source