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The Medicinal Chemistry of Caffeine [PDF]
Journal of Medicinal Chemistry, 2021 The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world and has multiple beneficial pharmacological activities, for example, in neurodegenerative diseases. However, despite being an extensively studied bioactive natural product, the mechanistic understanding of caffeine's pharmacological effects is incomplete.
Giuseppe Faudone +2 more
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Metallocyclodextrins in Medicinal Chemistry
Future Medicinal Chemistry, 2018This review focuses on metal complexes of cyclodextrin (CyD) derivatives designed for application as therapeutics or diagnostics. We discuss examples of metalloprotein models (hemoglobin, superoxide dismutase and catalase) based on cyclodextrins. The hydrophobic microenvironment of CyDs stabilizes the Fe(II) porphyrin system that can reversibly bind O2
Valentina Oliveri, Graziella Vecchio
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Polyethylenimine In Medicinal Chemistry
Current Medicinal Chemistry, 2008Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal ...
VICENNATI, PAOLA +3 more
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Furazans in Medicinal Chemistry
Journal of Medicinal Chemistry, 2021Incorporation of heterocycles into drug molecules can enhance physical properties and biological activity. A variety of heterocyclic groups is available to medicinal chemists, many of which have been reviewed in detail elsewhere. Oxadiazoles are a class of heterocycle containing one oxygen and two nitrogen atoms, available in three isomeric forms ...
Ross S. Mancini +3 more
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2003
In the past decade, nuclear magnetic resonance (NMR) spectroscopy has gained an enormous impact on drug research, due to its extraordinary capacity to measure properties and observe changes at individual atomic positions even in very complex systems. While the analysis of molecular structures still is the main goal of classical NMR investigations, it ...
M. Heller +5 more
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In the past decade, nuclear magnetic resonance (NMR) spectroscopy has gained an enormous impact on drug research, due to its extraordinary capacity to measure properties and observe changes at individual atomic positions even in very complex systems. While the analysis of molecular structures still is the main goal of classical NMR investigations, it ...
M. Heller +5 more
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2015
Identifying a compound or class of compounds that has biological activity at a particular biomolecular target is a necessary first step toward an eventual clinical candidate. In the vast majority of programs, however, many additional related compounds, possibly hundreds or even thousands, will need to be prepared and tested before a suitable molecule ...
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Identifying a compound or class of compounds that has biological activity at a particular biomolecular target is a necessary first step toward an eventual clinical candidate. In the vast majority of programs, however, many additional related compounds, possibly hundreds or even thousands, will need to be prepared and tested before a suitable molecule ...
openaire +2 more sources