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What is in Our Kit? An Analysis of Building Blocks Used in Medicinal Chemistry Parallel Libraries.
Journal of Medicinal Chemistry, 2021Building blocks are the molecular foundations for drug molecule design. The building block is one of the determining factors of final compound qualities in any given medicinal chemistry campaign.
Ying Wang +3 more
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Recent advancements on Benzimidazole: A versatile scaffold in medicinal chemistry.
Mini-Reviews in Medical Chemistry, 2021Benzimidazole is nitrogen containing fused heterocycle which has been extensively explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various biological activities such as anticancer, antimicrobial, anti-inflammatory ...
Zohor Mohammad Mahdi Alzhrani +2 more
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Spirocyclic Scaffolds in Medicinal Chemistry.
Journal of Medicinal Chemistry, 2020Spirocyclic scaffolds are incorporated in various approved drugs and drug candidates. The increasing interest in less planar bioactive compounds has given rise to the development of synthetic methodologies for the preparation of spirocyclic scaffolds. In
K. Hiesinger +3 more
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Metallocyclodextrins in Medicinal Chemistry
Future Medicinal Chemistry, 2018This review focuses on metal complexes of cyclodextrin (CyD) derivatives designed for application as therapeutics or diagnostics. We discuss examples of metalloprotein models (hemoglobin, superoxide dismutase and catalase) based on cyclodextrins. The hydrophobic microenvironment of CyDs stabilizes the Fe(II) porphyrin system that can reversibly bind O2
Valentina Oliveri, Graziella Vecchio
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Chemical Reviews
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date, five BCC drugs (including boronic acids and boroles) have been approved by the FDA for the treatment of cancer, infections, and atopic dermatitis, while some natural BCC ...
R. Grams +8 more
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Boron-containing compounds (BCC) have emerged as important pharmacophores. To date, five BCC drugs (including boronic acids and boroles) have been approved by the FDA for the treatment of cancer, infections, and atopic dermatitis, while some natural BCC ...
R. Grams +8 more
semanticscholar +1 more source
Triazoles in Medicinal Chemistry: Physicochemical Properties, Bioisosterism, and Application.
Journal of Medicinal ChemistryTriazole demonstrates distinctive physicochemical properties, characterized by weak basicity, various dipole moments, and significant dual hydrogen bond acceptor and donor capabilities.
Qianwen Guan +9 more
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Polyethylenimine In Medicinal Chemistry
Current Medicinal Chemistry, 2008Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal ...
VICENNATI, PAOLA +3 more
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Medicinal research reviews (Print), 2020
Morpholine is a heterocycle featured in numerous approved and experimental drugs as well as bioactive molecules. It is often employed in the field of medicinal chemistry for its advantageous physicochemical, biological, and metabolic properties, as well ...
A. Kourounakis +2 more
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Morpholine is a heterocycle featured in numerous approved and experimental drugs as well as bioactive molecules. It is often employed in the field of medicinal chemistry for its advantageous physicochemical, biological, and metabolic properties, as well ...
A. Kourounakis +2 more
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Acetylene Group, Friend or Foe in Medicinal Chemistry.
Journal of Medicinal Chemistry, 2020The use of an acetylene (ethynyl) group in medicinal chemistry coincides with the launch of the Journal of Medicinal Chemistry in 1959. Since then, the acetylene group has been broadly exploited in drug discovery and development.
T. Talele
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2003
In the past decade, nuclear magnetic resonance (NMR) spectroscopy has gained an enormous impact on drug research, due to its extraordinary capacity to measure properties and observe changes at individual atomic positions even in very complex systems. While the analysis of molecular structures still is the main goal of classical NMR investigations, it ...
M. Heller +5 more
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In the past decade, nuclear magnetic resonance (NMR) spectroscopy has gained an enormous impact on drug research, due to its extraordinary capacity to measure properties and observe changes at individual atomic positions even in very complex systems. While the analysis of molecular structures still is the main goal of classical NMR investigations, it ...
M. Heller +5 more
openaire +3 more sources