Results 131 to 140 of about 3,101 (283)

Make it double: identification and characterization of a Tandem-Hirudin from the Asian medicinal leech Hirudinaria manillensis. [PDF]

Parasitol Res, 2022
Lukas P, Melikian G, Hildebrandt JP, Müller C.   +3 more
europepmc   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Spectral responses across a dorsal-ventral array of dermal sensilla in the medicinal leech. [PDF]

J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2021
Groves TKH, Jellies JA.
europepmc   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

The genome of medicinal leech (Whitmania pigra) and comparative genomic study for exploration of bioactive ingredients. [PDF]

BMC Genomics, 2022
Tong L, Dai SX, Kong DJ, Yang PP, Tong X, Tong XR, Bi XX, Su Y, Zhao YQ, Liu ZC.   +9 more
europepmc   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

A new species of medicinal leech in the genus Hirudo Linnaeus, 1758 (Hirudiniformes, Hirudinidae) from Tianjin City, China. [PDF]

Zookeys, 2022
Wang H, Meng FM, Jin SJ, Gao JW, Tong XR, Liu ZC.   +5 more
europepmc   +1 more source

TLRs EXPRESSION IN THE MEDICINAL LEECH [PDF]

, 2018
It is well known that Toll-like receptors (TLRs) play a central role for innate immunity in both in vertebrates and many invertebrates, by recognizing conserved pathogen-associated molecular patterns in order to trigger the innate immune response. Here,
N BARANZINI, M DE EGUILEOR, R GIRARDELLO, A GRIMALDI   +3 more
core  

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

The medicinal leech as a useful tool for studying haematopoiesis, angiogenesis and innate immune response

, 2017
In the last decade, a large body of evidence has demonstrated that hematopoiesis, angiogenesis, immune response and cytokines regulating the occurrence of these processes have been highly conserved across Vertebrates and various invertebrate phyla.
M de Eguileor, R Girardello, Grimaldi, G Tettamanti, N Baranzini   +4 more
core