Advanced Science, EarlyView.This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka +4 more
wiley +1 more source
Traditional Chinese Medicinal Leech Induces Apoptosis and Autophagy in Glioblastoma by SGK1/Caspase-3 and PI3K/AKT/mTOR Pathway. [PDF]
CNS Neurosci TherWu S, Zhou Y, Pei Z, Wang Y, Zhang Z.
europepmc +1 more source
Closed Genome Sequence of Aeromonas veronii Strain Hm21, an Isolate from the Medicinal Leech Hirudo verbana. [PDF]
Microbiol Resour Announc, 2020 Graf J, Nelson MC, Colston SM.
europepmc +1 more source
Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source
Incomplete versus Sustained Innate-Immune Responses in the Medicinal Leech following Chronic, Environmentally Relevant Per- and Polyfluoroalkyl Substance Exposure. [PDF]
Environ Health (Wash)Baranzini N +8 more
europepmc +1 more source
Draft genome of the European medicinal leech Hirudo medicinalis (Annelida, Clitellata, Hirudiniformes) with emphasis on anticoagulants. [PDF]
Sci Rep, 2020 Kvist S +4 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon +20 more
wiley +1 more source
Tissue regenerative potential of human dental pulp mesenchymal stem cell conditioned medium in wound healing of the medicinal leech. [PDF]
Stem Cell Res TherMarcolli G +11 more
europepmc +1 more source