Results 111 to 120 of about 471,648 (295)
Immunomodulator Activity Of An Isolate From Artocarpus Champeden Spreng. On Cytotoxicity Function Of Cd8+ Of Mice [PDF]
, 2011 Research of traditional medicine is important to maximize the utilization of natural resources. Artocarpus champeden Spreng. is one of medicinal plants that must be studied because a lot of diseases have been treated traditionally with this plant, such ...
Kartini, Kartini
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Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins
Gastroenterology Research and Practice, 2012 Isolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility.
Yun-Jie Dang +4 more
doaj +1 more source
Eksplorasi Tumbuhan Obat Pada Taman Nasional Gunung Leuser, Resort Sei Betung, Sumatera Utara [PDF]
, 2015 Medicinal plants have a very important role for world health that need to be done of research to analyze the diversity of medicinal plants. Medicinal plants exploratory research had been done in the Gunung Leuser National Park, Sei Betung Resort from ...
Afifuddin, Y. (Yunus) +2 more
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Value Addition to Local Kani Tribal Knowledge: Patenting, Licensing and Benefit-Sharing [PDF]
The subject of this case study is the role of intellectual property rights in the benefit-sharing arrangements concerning the "Jeevani" drug, which was developed by scientists at the Tropical Botanic Garden and Research Institute (TBGRI), based on the ...
Gupta, Anil K.
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The safety of herbal medicinal products [PDF]
, 2011 The primary aim of the EU, with the registration of herbal medicinal products (HMPs), is the protection of the European citizens from fraudulent and unsafe products.
Attard, Everaldo
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source