Results 121 to 130 of about 219,336 (313)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Traditionaly utilization of Selaginella; field research and literature review [PDF]

, 2009
Setyawan AD. 2009. Traditionaly utilization of Selaginella; field research and literature review. Nusantara Bioscience 1: 146-154. The aims of this research were to find out traditional usage of Selaginella in medication and its other usages ...
SETYAWAN, AHMAD DWI
core  

Deep sequencing of plant and animal DNA contained within traditional Chinese medicines reveals legality issues and health safety concerns

, 2012
Traditional Chinese medicine (TCM) has been practiced for thousands of years, but only within the last few decades has its use become more widespread outside of Asia. Concerns continue to be raised about the efficacy, legality, and safety of many popular
Michael Bunce, Haile, James, Jayne Houston, Haile James, White Nicole E., Bellgard, Matthew I., Megan L Coghlan, Paula Moolhuijzen (171379), Paula Moolhuijzen, Dáithí C. Murray (171368), Bellgard, M.I., Houston Jayne, Murray, D.C., Houston, Jayne, Dáithí C Murray, White, N.E., Coghlan, Megan L., James Haile (40135), Jayne Houston (171362), Coghlan, Megan, Bellgard Matthew I., Coghlan Megan L., Matthew I. Bellgard (171383), Coghlan, M.L., Matthew I Bellgard, Murray Dáithí C., Moolhuijzen, Paula, Megan L. Coghlan (171354), White, Nicole E., Nicole E. White (171373), Moolhuijzen, P., Haile, J., White, Nicole, Houston, J., Bellgard, M., Moolhuijzen Paula, Murray, D., Michael Bunce (31164), James Haile, Murray, Dáithí C., Nicole E White, Bunce, M., Bunce Michael, Bunce, Michael   +43 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Globalisation and sustainable exports of Indian medicinal and aromatic plants: A protection study

India has a rich heritage of traditional systems of medicine viz. Ayurveda, Unani, Siddha, Tibetan which are mostly based on botanical formulations. Although biologically, the region is extremely rich in medicinal plants, due to years of unwise use, the ...
Bera, Soumitra Kumar
core  

POTENTIAL OF MEDICINAL PLANT EXTRACTS IN INDUCING PLANT RESISTANCE ON GINGER AGAINST BACTERIAL WILT DISEASE

, 2020
Bacterial wilt caused by Ralstonia solanacearum is one of the mostdestructive diseases on ginger. The aim of this study was to evaluate thepotential use of five different medicinal plants extracts (Acalypha indica,Andrographis paniculata, Centella ...
SUPRIADI, SUPRIADI; Indonesian Spice and Medicinal Crops Research Institute Balai Penelitian Tanaman Rempah dan Obat Jalan Tentara Pelajar No. 3, Bogor 16111, HARTATI, SRI YUNI; Indonesian Spice and Medicinal Crops Research Institute Balai Penelitian Tanaman Rempah dan Obat Jalan Tentara Pelajar No. 3, Bogor 16111, RAHAYUNINGSIH, SRI; Indonesian Spice and Medicinal Crops Research Institute Balai Penelitian Tanaman Rempah dan Obat Jalan Tentara Pelajar No. 3, Bogor 16111   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source