Results 141 to 150 of about 219,336 (313)

Phytochemical Constituents and Physicochemical Properties of Medicinal Plant (Moringa Oleifera) Around Bule Hora [PDF]

open access: yes, 2014
The investigation was carried out a qualitative test for the possible phytochemical components (Alkaloids, Phenolic compound, Quinone, Protein, Anthraquinones, Saponins, Coumarin, Flavonoids, Tannin Fixed oil and fats and Steroid-glycosides) and ...
Ibrahim Kassa Belay
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Shifting from Agriculture to Agribusiness: The Case of Aromatic Plants

open access: yes
This study has examined the agribusiness opportunities in medicinal and aromatic plants (MAPs), based on the field level information from the state of Uttarakhand. The financial feasibility of important aromatic plants has been studied. It has been found
Mittal, Rashi, Singh, S.P.
core  

Medicinal plant recipes from Kirklareli

open access: yes, 2014
In this study, have been reported different medicinal plant recipes in the Kirklareli region. 15 medicinal plant recipes belonging to 20 families (20 wild plant species, 7 cultivated plant species) which were used for different medicinal purposes by ...
KÜLTÜR, Şükran
core  

From Species to Varieties: How Modern Sequencing Technologies Are Shaping Medicinal Plant Identification

open access: yes
Background/Objectives: Modern sequencing technologies have transformed the identification of medicinal plant species and varieties, overcoming the limitations of traditional morphological and chemical approaches.
Mingcheng Wang   +4 more
core   +1 more source

Production of colchicine by using plant cell culture [PDF]

open access: yes, 2005
Plant cell and tissue culture is an established alternative to the harvest and extraction of whole plant material for the production of valuable secondary metabolites.
Aroud, Gamal
core  

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