Results 211 to 220 of about 219,336 (313)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Evolutionary dynamics and phylogenetic analysis of the mitochondrial genome of the medicinal plant Peucedanum praeruptorum. [PDF]

BMC Plant Biol
Li J, Yu X, Deng L, Xie R.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro bioactive metabolite production and plant regeneration of medicinal plant Ligusticum chuanxiong Hort. [PDF]

BMC Plant Biol
Chen S, Wei X, Chen X, Mao Q, Li R, Zhen Y, Xing Y, Wu M, Song C, Jiang G, Yin X.   +10 more
europepmc   +1 more source

Assessing the impacts of climate change on the potential distribution of the medicinal plant <i>Bidens biternata</i> in China using Biomod2. [PDF]

Front Plant Sci
Liu Y, Zhang P, Zhang H, Gao W, Luo H, Liu S, Hu J.   +6 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Morphological characterization of Calotropis procera (Aiton) W.T. Aiton, a neglected medicinal plant. [PDF]

PLoS One
Khadivi A, Mirheidari F, Tunç Y, Saeidifar A, Moradi Y, Rabiei V, Razavi F.   +6 more
europepmc   +1 more source

Comprehensive analyses of different putative ploidy levels in organelle genomes of an important medicinal plant Polygonatum kingianum Collett & Hemsl. [PDF]

BMC Plant Biol
Zhao J, Chen ZH, Zhang MX, Wang LH, Yang XY, Wang JG, Zhu YY, Li XY, Zhao Y.   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source