Results 81 to 90 of about 4,480,788 (209)

Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

Journal of Pharmaceutical Analysis, 2020
The recent pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has raised global health concerns. The viral 3-chymotrypsin-like cysteine protease (3CLpro) enzyme controls coronavirus replication and is essential for its life cycle ...
Muhammad Tahir ul Qamar, Safar M. Alqahtani, M. Alamri, Ling-Ling Chen   +3 more
semanticscholar   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Identification and validation of reference genes for quantitative real-time PCR in Corydalis saxicola under various abiotic stresses

Scientific Reports
Quantitative real-time PCR (qRT-PCR) is a commonly used method for measuring gene expression, but its accuracy depends on the use of stable reference genes for data normalization.
Liang Kang, Zhaodi Wen, Han Liu, Ying Lu, Mei Qin, Lirong Huang, Ming Lei, Cui Li, Dan Zhu, Li Li, Zhanjiang Zhang   +10 more
doaj   +1 more source

The complete chloroplast genome of Epimedium brevicornu (Berberidaceae), a traditional Chinese medicinal herb

Mitochondrial DNA. Part B. Resources, 2020
Epimedii Folium has been used as a common traditional Chinese medicine for more than 2000 years in China. In this study, we assembled the complete chloroplast (cp) genome of Epimedium brevicornu. The whole cp genome of E.
Yu Yao, Xiang Liu, Qianru Yang, Yanjiao Luo, Cheng Zhang, Chaoqun Xu, Fengmei Suo, Guoan Shen, Baolin Guo   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Biotransformation of characteristic saponins and pharmacological compounds in Panax notoginseng by the golden flower fungus Aspergillus cristatus

Medicinal Plant Biology
Panax notoginseng, an important traditional Chinese medicine with a long history of clinical application, possesses significant pharmacological value. P.
Qi Wei, Jialong Song, Lei Wang, Meiyi Li, Hang Ji, Chuhan He, Huiyan Ju, Shouan Liu   +7 more
doaj   +1 more source

The complete chloroplast genome of Epimedium xichangense Y. J. Zhang (Berberidaceae)

Mitochondrial DNA. Part B. Resources, 2020
Epimedium xichangense, a critically endangered herb with limited population, mainly distributes in Sichuan province, China. In our study, we obtained the complete chloroplast genome of E.
Yuanyue Wang, Xiang Liu, Cheng Zhang, Chaoqun Xu, Fengmei Suo, Guoan Shen, Baolin Guo   +6 more
doaj   +1 more source

Medicinal plants meet modern biodiversity science.

Current Biology
Plants have been an essential source of human medicine for millennia. In this review, we argue that a holistic, interdisciplinary approach to the study of medicinal plants that combines methods and insights from three key disciplines - evolutionary ...
Charles C. Davis, Patrick Choisy
semanticscholar   +1 more source