Results 41 to 50 of about 2,392,590 (304)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cancer Niche as a Garbage Disposal Machine: Implications of TCM-Mediated Balance of Body-Disease for Treatment of Cancer. [PDF]

, 2019
Cancer epidemic led to worldwide to search for a new "game changer" concept to govern cancer research and cancer treatment. Western medicine-based cancer research has been extending the impasse without resolution in sigh for improving survival of ...
Lee, Katherine L, Li, Shengwen Calvin, Luo, Jane   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Efectividad de la tintura de propóleo al 5 % en el tratamiento de la gingivitis descamativa crónica

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2015
Fundamento: la Medicina Natural y Tradicional (MNT) ha ganado un lugar relevante en la terapéutica de múltiples afecciones estomatológicas, siendo los apifármacos, como la tintura de propóleo, ejemplo fehaciente de estos logros.
Omelio Fontaine Machado, Ana María García Jiménez, Yadira Rosales Ramírez, María Elena Mawad Santos, María del Carmen Fontaine Uliver   +4 more
doaj  

Protocol for Systematic Review of Controlled Trials of Korean and Chinese Herbal Treatments for Stroke [PDF]

Journal of Acupuncture Research, 2017
Background Many stroke patients receive traditional medical care in Korea and China. Stroke patients comprise the largest proportion of inpatients in traditional Korean medicine and traditional Chinese medicine hospitals.
Ju-Ah Lee, Tae-Young Choi, Myeong Soo Lee, Mimi Ko, Byoung-Kab Kang, Huan Liu, Jun-Jie Jiang, Yuan-Yuan Li   +7 more
doaj   +1 more source

The Forensic Characterization of Bacterial and Fungal Organisms in Traditional Chinese Medicine [PDF]

, 2018
There has been an increase in use of Traditional Chinese Medicine (TCM) in the United States because they are less expensive and believed to be more effective with less adverse effects in comparison to traditional pharmaceutics.
Ehrhardt, Christopher J, Grzymkowski, Julia, Peace, Michelle R, Poklis, Justin L   +3 more
core   +1 more source

Hare-lip surgery in the history of traditional Chinese medicine [PDF]

, 2000
There have been a few articles published in Chinese and English on hare-lip surgery in the history of traditional Chinese medicine. They are brief and some of them are inaccurate, although two recent English articles on this subject have presented an ...
Ma, K
core   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Efectividad del extracto acuoso de aloe en el tratamiento de las alveolitis bucales

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2015
Fundamento: la alveolitis es una complicación que puede aparecer luego de las exodoncias, se considera una urgencia estomatológica por el dolor intenso.
Isidro de Jesús Nápoles González, Mirian Cuan Corrales, María del Carmen Sospedra Blanco, Sury Rosa Árias Herrera, Oscar Rivero Pérez   +4 more
doaj