Results 41 to 50 of about 2,235,667 (290)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

In vitro antimicrobial effect of the plant Boldoa purpurascens Cav. (Nitro) in the fimbria of Escherichia coli

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018
Background: the plant Boldoa purpurascens Cav. (Nitro) has traditionally been considered useful for urinary tract diseases. It constitutes a therapeutic potential for the development of effective pharmaceutical forms.Objective: to evaluate the in vitro ...
Carlos Manuel Jiménez-Martínez, Dunia Ramos-López, Yisell Urquiza-Yero   +2 more
doaj  

The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine. [PDF]

, 2020
This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data.
Bergan, Raymond, Dickson, Dane, Johnson, Jennifer, Kurzrock, Razelle, Owens, Rebecca, Subbiah, Vivek   +5 more
core  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Nivel de conocimientos de Medicina Natural y Tradicional en estudiantes de quinto año de la carrera de Medicina

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016
Fundamento: la Medicina Natural y Tradicional constituye una prioridad en el sistema de salud cubano, su enseñanza en la carrera de Medicina, desde el curso 2010/2011, se efectúa a través de una estrategia curricular.Objetivo: caracterizar la percepción ...
Marcia Maricela Cuervo Calviño, Sahily Rojas Pérez, Ricardo Marciano Ramírez Oquendo   +2 more
doaj  

Iranian traditional medicine and Medicinal plants

International Journal of Plant Science and Horticulture, 2019
Traditional medicine is a general word referring to both tradiotional medicine systems and to Native medicine. Iranian traditional medicine is a great history of medicine and pharmacy.to inform the importance of Iranian traditional medicine we may state great evidences such as: Makhzan-ol-advie by Aghili (18th century, Tehran University of Medical ...
Reza Esmaeelzadeh Dizaji, Ashrafali Rezaie kehkhaie, Mohammad Taqi khammar, Reza shirazinia   +3 more
openaire   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Observation of antitumor mechanism of GE11-modified paclitaxel and curcumin liposomes based on cellular morphology changes

AAPS Open
Curcumin and paclitaxel are widely used as anti-tumor hydrophobic model drugs for the designation of smart tumor-targeting nanocarriers and the study of the correlation between structural characteristics of nanoparticles and in vivo therapeutic efficacy.
Hailing Tang, Lijuan Li, Baoshan Wang, Guangxi Scientific Research Center of Traditional Chinese Medicine   +3 more
doaj   +1 more source

Radical liberal values-based practice. [PDF]

, 2011
Values based practice is a radical view of the place of values in medicine which develops from a philosophical analysis of values, illness and the role of ethical principles. It denies two attractive and traditional views of medicine: that diagnosis is a
Beauchamp, Beauchamp, Boorse, Fulford, Fulford, Gascoigne, Hare, Kendell, Macklin, Rubin, Sadler, Szasz, Thornton, Thornton, Wakefield, Wakefield   +15 more
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source