Results 111 to 120 of about 19,758,671 (409)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Radiation exposure from diagnostic nuclear medicine examinations in golestan province [PDF]
Introduction: The aim of present study was to estimate effective dose from most common procedures performed in nuclear medicine departments of Golestan province.
Asli, I.N. +6 more
core
A pre and post intervention study to reduce unnecessary urinary catheter use on general internal medicine wards of a large academic health science center [PDF]
Krista Wooller +5 more
openalex +1 more source
Senior medical students as assistants in medicine in COVID-19 crisis: a realist evaluation protocol [PDF]
Lynn V. Monrouxe +8 more
openalex +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Nuclear medicine: investigation of renal function in small animal medicine [PDF]
Kidney function investigations in veterinary medicine are traditionally based on blood analysis (blood urea nitrogen (BUN) and serum creatinine concentration) and / or urinalysis (urine specific gravity, protein-to-creatinine ratio or fractional ...
De Sadeleer, Carlos +7 more
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A new initiative on precision medicine.
Francis S. Collins, Harold Varmus
semanticscholar +1 more source

