ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Redefining social medicine from Latin America: Historical foundations and contemporary directions. [PDF]
PLOS Glob Public HealthOrtega F, Abarca-Brown G.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Corrigendum to "Incidence and associated factors of major VCI in first-ever ischemic stroke patients with mild VCI: a five-year prospective cohort study" [The Lancet Regional Health - Western pacific Volume 67, February 2026, 101800]. [PDF]
Lancet Reg Health West PacLee HS +16 more
europepmc +1 more source
PLoS Medicine series on Big Food: the food industry is ripe for scrutiny. [PDF]
PLoS Medicine, 2012 PLoS Medicine Editors
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
AAFP: AAFP Residency Initiative Leads Impactful Changes for 2027 Match. [PDF]
Ann Fam MedMitchell D, AAFP News.
europepmc +1 more source
Thirty ways to improve the health of the world's poorest people. [PDF]
PLoS Medicine, 2007 PLoS Medicine Editors
doaj +1 more source